Effects Of Daily Walking Counts On The Motor Function And Quality Of Life In Wilson's Disease

Background and Objective:Wilson's disease(WD)is an autosomal recessive inherited disorder with copper metabolism,treatments including chelation drugs therapy,symptomatic therapies and liver translation.Although some motor disorders may be alleviated with drug therapy,characteristics such as tremor,dystonia and gait disturbance become less responsive to medication as time goes on,even with the optimized treatment.With regard to movement disorder,there are a few researches demonstrating that rehabilitation therapy can improve motor functions in patients with Parkinson's disease.In this study,we recorded daily walking counts in patients with Wilson's disease,in order to analyze the effect of different intensity of walking on motor function and quality of life in patients with Wilson's disease.Exploring the value of walking training in rehabilitation of patients with Wilson's diseaseMethods:From December 2017 to October 2018,26 patients with Wilson's disease who were admitted to the First Affiliated Hospital of Fujian Medical University were included in the study.All participants were with neurological subtype,disease duration more than 6 months and stable medication use.General situation and clinical data of all participants were collected.We Chat pedometer were used to monitor daily walking counts in them.We evaluated effects on UWDRS scores and WHO Qo L-BREF scores in baseline and after 3 months,as well as correlative factors among UWDRS scores,WHO Qo L-BREF scores and daily walking counts in all subjects.Results:1.Patients were divided into high intensity walking group with median of daily walking counts more than 6000(14 patients),low intensity walking group was with median of daily walking counts less than 6000(12 patients).There was no significant difference in gender,age at onset and duration between two groups.2.The UWDRS neurological subscore in high intensity walking group was significantly decreased than low intensity walking group at 3 months,difference was statistically significant(P<0.05),meanwhile,the Qo L-BREF Physical domain subscore in high intensity walking group was significantly promoted than low intensity walking group(P<0.05).3.The UWDRS and UWDRS neurological subscore at 3 months of high intensity walking group were significantly lower than baseline,difference was statistically significant(P<0.05).4.Single factor analysis demonstrated that baseline UWDRS neurological subscore was related with daily walking counts(P<0.05),while age,gender and disease duration were not related with daily walking counts(P>0.05).5.UWDRS neurological subscore and Qo L-BREF Physical domain subscore were not related with age,gender and disease duration(P>0.05).Conclusion:There is a difference in daily walking counts among WD patients,which is related with baseline UWDRS neurological subscore.High intensity walking can improve the neurological symptoms in patients with Wilson's disease.High intensity walking can enhance quality of life,especially physical domain.High intensity walking is expected to become a nonpharmacological treatment for Wilson's disease.