| Objective: To investigate whether there is a significant difference in accuracy of the two-sided electrode implanted during the same period in Parkinson’s disease with subthalamic nucleus deep brain stimulation(STN-DBS),and whether the accuracy affects the bilateral postoperative effects.Methods: Twenty-nine PD patients admitted in our department from January 2016 to December 2018,who underwent bilateral STN-DBS surgery were re-examined with CT scanning on the head after bilateral electrodes were implanted during the operation.The results were merged with preoperative 3T-MRI images(with planned targets).The implanted electrodes were measured and calculated error distance from the planned targets.Unified Parkinson’s Disease Rating Scale Ⅲ(UPDRSⅢ)was used to evaluate the improvement of the symptoms before and in 6 months after operation.Pearson correlation analysis were used to study the correlation among age,gender,age of onset and duration of disease withimprovement rate and deviation.Results: Finally,27 patients were enrolled,54 electrodes were implanted successfully.There was no significant differences in the age,gender,onset age and course of disease and the improvement rate and deviation among these patients(P>0.05).No obvious difference was seen in the mean deviation between the first implanted electrodes and second implanted electrodes(t=1.437,P>0.05).The symptoms of all patients were obviously improved.In 6 months after surgery,the average improvement rate of systemic symptoms was(78.10±10.25)% with drug on,and the average decrease of the equivalent dose of levodopa was 45.07%.The improvement rate was(83.15 ± 9.16)% for the first side,and(83.52± 11.21)% for the second side.There was no significant difference in the improvement of limb symptoms between the two sides(P > 0.05).Conclusion: The accuracy of simultaneous implantation of bilateral electrodes in STN-DBS is not significantly different,while still achieving good clinical outcomes. |
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