Analysis Of Clinical Characteristics Of 36cases Of Extramammary Paget’s Disease

Objective: To evaluate the features of extramammary Paget’s disease by retrospectively studying cases.Methods: The clinical data of patients with extra-mammary Paget disease diagnosed in the First Affiliated Hospital of Chongqing Medical University from January 1,2013 to December 31,2018 were collected.Statistical analyses were performed based on the clinical data.Results: A total of 36 cases were sampled in this study.Extramammary Paget’s disease usually occurred in males with a ratio of 3:1;The average age of onset was(65.72±10.41)years;The course of disease ranged from 6 months to 10 years with a mean of 4 years;Single lesions accounted for the majority,and the most common site was the scrotum(50.00%);The main lesions were erythema and erosion(91.67%);60.61% of the patients were misdiagnosed;Immunohistochemistry was mainly positive for CK7,CEA,and EMA;30 cases had no metastasis while6 cases did;30 patients underwent extended local excision and intraoperative frozen section,and 2 out of them relapsed;Among the 30 surgical cases,27 patients had a clear resection range most of which were about 1cm and 2cm.The extended resection of 2 cm had a relatively higher one-time total excision rate of 90.91%.Conclusion: Extramammary Paget’s disease is more common in males and the elders with a high rate of misdiagnosis.Most of the EMPD lesionsare single.Primary or secondary can be distinguished by immunohistochemistry.With a slow progression,extramammary Paget’s disease can still metastasize.Extended local excision is the main treatment while some cases may relapse,2 cm is suggested as the extended resection.