An Analysis Of Risk Factors In Very Low Birth Weight Infants With Necrotizing Enterocolitis

Objective: To investigate the risk factors of necrotizing enterocolitis(NEC)in very low birth weight infants(VLBWI).Methods: A retrospective study of VLBWI admitted to the Children's Hospital of Chongqing Medical University from Jan.2011 to Oct.2019 was conducted.Infants were assigned into two groups: NEC group(Bell stage ??)and non-NEC group.The data were measured with the Student's t-test,Kruskal-Wallis test,chi-square or the Fisher's exact statistic test.Logistic regression analysis was used to identify independent risk factors associated with NEC.Results: Of 497 VLBWI enrolled,30 infants developed NEC.No significant differences were found in birth weight,gestational age,gender,admitted age and perinatal information between the group with NEC and the other group without NEC.Higher incidences of in vitro fertilization and embryo transfer(IVF-ET)(P=0.025),intrauterine growth retardation(IUGR)(P=0.015),atrial septal defect(P=0.014),renal dysfunction(P=0.012),liver dysfunction(P=0.003),hypoalbuminemia(P=0.002),electrolyte disorder(P=0.041),and sepsis(P<0.001)were found in infants with NEC compared with those without NEC.Logistic regression analysis revealed sepsis(OR 13.24,95%CI 4.04-43.36,P<0.001),hypoalbuminemia(OR 4.22,95%CI 1.14-15.58,P=0.031),IUGR(OR 3.46,95%CI 1.18-10.14,P=0.024)and IVF-ET(OR 4.85,95%CI 1.5-15.68,P=0.008)were the risk factors of NEC in VLBWI.Conclusion: We should keep an eye on sepsis,hypoalbuminemia,IUGR and IVF-ET among VLBWI,which are the risk factors of NEC.