| Objective: To explore the efficacy and safety of high dose immunoglobulin(IVIG)in the treatment of severe JE.Methods: A retrospective study of 124 children diagnosed with severe or extremely severe JE was performed in a 6-month retrospective study.There were 62 cases in the IVIG group and the control group.The efficacy,safety and tolerability of the drug were evaluated 3 days,1 week,2 weeks,and 3 weeks after IVIG,respectively,and the prognosis was assessed at 6 months.Results:(1)The valid rate of the IVIG group at each stage of treatment(1 week,2 weeks,3 weeks)was significantly higher than that of the control;Cumulative survival function suggested that the IVIG group reached the effective treatment end point faster than the control group;(2)The duration of unconsciousness,the days of seizures,the days of dull response to light,the pyramidal sign and the meningeal irritation sign in the IVIG group were shorter than those in the control group(P <0.05);The number of complications occurred in the IVIG group including gastrointestinal bleeding and pneumonia was less than the control group(P <0.05);(3)Cox regression survival analysis suggested that age(p = 0.003)and imaging abnormalities(p = 0.042)had an effect on the efficacy of IVIG;(4)Liverpool score with a course of 6 months showed that the prognosis of the IVIG group was better than that of the control group(P <0.05);(5)IVIG had proper safety and tolerability.Conclusion: IVIG has good efficacy,safety and tolerance for the treatment of severe Japanese encephalitis;The age and imaging abnormalities affect the efficacy of IVIG. |
