| Objective: To observe the efficacy and safety of Fuzi Lizhong decoction combined with Leihuo moxibustion in the treatment of diarrhea IBS-D,to provide effective diagnosis and treatment for diarrhea type irritable bowel syndrome.Methods: According to the inclusion exclusion criteria,66 patients with IBS-D were randomly divided into the experimental group and the control group of 33 cases.The patients in both groups were treated by adjusting their daily life,improving their diet structure and adjusting their emotions.On this basis,the experimental group was treated with "Fuzi Lizhong decoction combined with external Leihuo Moxibustion",and the control group was treated with "trimebutine maleate combined with Bifidobacterium triple viable capsule".Both groups were treated for 4 weeks,and the changes of TCM syndrome score,IBS-SSS score,abdominal pain and diarrhea response rate,quality of life score and safety index were observed,and statistical analysis was carried out to evaluate the effectiveness and safety of Fuzi Lizhong decoction combined with Leihuo moxibustion in the treatment of "Taiyin Shaoyin Hanli" IBS-D.Result:1.In this study,66 patients were included,33 in the experimental group and 33 in the control group,of which 61 patients completed the clinical observation,31 in the experimental group and 30 in the control group,with a total exfoliation rate of 7.58%;2.There was no significant difference between the two groups in gender,age,course of disease,TCM syndrome distribution,IBS-SSS pre-treatment score,IBS-QOL pre-treatment score(P > 0.05);3.In the aspect of TCM syndrome efficacy,after 4 weeks of treatment,the total effective rate of the experimental group was 90.32%,the total effective rate of the control group was70.00%,and the efficacy and the total effective rate of the experimental group were better than those of the control group(P<0.05);In the aspect of TCM syndrome total score,the scores of the two groups after treatment were lower than before treatment(P< 0.05),and the experimental group was better than the control group(P< 0.05);In the aspect of each single integral of TCM syndrome,the two groups were compared before and after treatment,for the treatment of fatigue,there was no statistical difference in the control group before and after treatment(P>0.05),but the score of the test group before and after treatment decreased(P<0.05),there was significant difference in other symptoms between the two groups(P<0.05);There was no significant difference between the two groups in the improvement of abdominal cold pain,diarrhea,defecation frequency,self-interest and thirst,waist and knee tenderness(P>0.05),but in the aspects of warm,cold and fatigue,there was significant difference between the two groups(P<0.05),and the experimental group was better than the control group(P<0.05);4.In the aspect of abdominal pain and diarrhea response,after 4 weeks of treatment,the abdominal pain response and diarrhea response of the experimental group were 77.42% and70.97%,respectively,which were higher than those of the control group,53.33% and 43.33%,with statistical significance(P<0.05);5.In terms of IBS-SSS efficacy,after 4 weeks of treatment,9 cases in the experimentalgroup were effective,19 cases were effective,3 cases were ineffective,3 cases in the control group were effective,20 cases were effective,7 cases were ineffective,and the efficacy of the experimental group was better than that of the control group(P<0.05);The total effective rate was 90.32% in the experimental group and 76.67% in the control group,with no significant difference(P>0.05);In terms of IBS-SSS scores,the scores of both groups after treatment were lower than those before treatment,and the experimental group is better than the control group,the difference was statistically significant(P<0.05);6.In terms of IBS-QOL score,both groups could significantly improve the quality of life of patients(P<0.01),and the experimental group was better than the control group(P<0.05);7.In terms of safety and adverse reactions,there were no clinically significant abnormal changes in blood analysis,urine analysis,stool routine + ob,electrolytes,renal function,liver function,ECG,abdominal color ultrasound and physical examination before and after treatment in the two groups;no adverse reactions and events were observed in both groups.Conclusion: The combination of Fuzi Lizhong Decoction and Leihuo moxibustion can significantly improve the TCM clinical syndrome,IBS-SSS score and IBS-QOL score of the patients with "Taiyin Shaoyin Hanli" diarrhea type irritable bowel syndrome,with definite clinical effect and good safety. |
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