Clinical Observation Of Zishui Hanmu Method Combined With TACE In The Treatment Of Primary Hepatic Carcinoma (Yin Deficiency Of Liver And Kidney)

Objective:To compare the effect of Zishui Hanmu method(combined Yiguanjian decoction with Sanyinjiao acupoint moxibustion)combined with transarterial chemoembolization(TACE)and conventional TACE on the patient's clinical syndromes of traditional chinese medicine(TCM),quality of life,alpha fetoprotein(AFP),C-reactive protein(CRP),liver function and major adverse reactions(fever,nausea and vomiting,abdominal pain,bone marrow inhibition)in the treatments of primary hepatic carcinoma(Yin deficiency of liver and kidney),to explore the clinical efficacy and safety of Zishui Hanmu method combined with TACE in the treatment of primary hepatic carcinoma,and to enrich the treatment plan for clinical liver cancer after TACE at the same time.Methods:In this study,126 patients with primary hepatic carcinoma(Yin deficiency of liver and kidney)were selected according to syndrome differentiation,and were randomly divided into a control group(n=63)and an observation group(n=63)by random number table.The control group used TACE and western medicine routine treatment,the observation group is based on the control group combined with Zishui Hanmu method,treatment time is 4 weeks.Before and after treatment,both groups were recorded and evaluated changes in TCM syndrome score,karnofsky performance status(KPS),AFP value,CRP value,liver function and postoperative adverse reactions,and the t test and chi-square test were used.And non-parametric tests and other statistical methods for analysis.Results:1.A total of 126 patients were included in this study,of which 120 patients completed the clinical observation,and the observation group and the control group each fell off and eliminated3 patients;2.The baseline data of the two groups of patients before treatment,the difference was not statistically significant(P>0.05);3.After treatment,the curative effect of TCM Syndrome of the two groups of patients was compared.The observation group improved more than the control group.After statistical analysis,the difference was statistically significant(P<0.05);4.After treatment,the KPS scores of the two groups of patients were higher than before treatment,and the KPS score and efficacy of the observation group improved more significantly,the difference was statistically significant(P<0.05);5.After treatment,the AFP value of both groups of patients decreased,and the observation group decreased more significantly than the control group,the difference was statistically significant(P<0.05);6.One week after operation,the CRP value of patients in the observation group decreased compared with before(P <0.05),while the CRP value of patients in the control group before and after treatment was compared,and there was no statistically significant difference(P>0.05);7.After treatment,the liver function indexes of the two groups of patients improved,and the observation group had improved albumin(ALB),aspartate aminotransferase(AST),and alanine aminotransferase(ALT)levels compared with the control group obviously,the difference was statistically significant(P<0.05),and the total bilirubin(TBIL)level between the two groups wasnot statistically significant(P>0.05);8.In terms of major adverse reactions,after treatment,it was found that except for the occurrence of myelosuppression between the two groups of patients(P > 0.05),the number of patients in the observation group who developed fever,nausea,vomiting and abdominal pain were less than the control group(P < 0.05),and graded according to the severity of adverse reactions,the incidence of adverse reactions in the observation group was also lighter than that in the control group,and the differences were statistically significant(P<0.05).Conclusion:Zishui Hanmu method combined with TACE in the treatment of patients with primary hepatic carcinoma(Yin deficiency of liver and kidney)has good clinical efficacy.It can not only improve the clinical symptoms of TCM and liver function of patients,improve the quality of life of patients,assist in reducing AFP values and alleviate patients' surgery.Postinflammatory reaction can also effectively reduce the occurrence of postoperative adverse reactions in patients and improve the TACE prognosis of liver cancer patients.It is a safe and effective treatment method and is worthy of clinical promotion.