| Purpose:The purpose of this study was to discuss the expression and clinical significance of the mismatch repair proteins MLH1,MSH2,MSH6,PMS2 deletion and MMR functional status in colorectal cancer.At the same time,the risk factors of colorectal cancer patients with complete follow-up data were analyzed to explore the correlation between MMR function status and the 3-year prognosis of colorectal cancer patients.Methods:1.A retrospective collection of 1560 cases of clinicopathological data of patients with rectal cancer who underwent surgical treatment in the Department of Gastroenterology at the First Affiliated Hospital of Air Force Military Medical University from January 2010 to December 2016.According to the loss of mismatch repair protein,the MMR functional status is judged.The four mismatch repair proteins and MMR functional status were statistically analyzed with the pathology of colorectal cancer to find correlations.2.Patients with colorectal cancer who underwent surgery and were discharged from September 2014 to December 2016 were followed up dynamically and completed 3 years of follow-up.Statistical analysis of colorectal cancer patients’ 3-year total prognosis and tumor pathology was completed.Results:1.1.Univariate analysis showed that there was a statistically significant difference between the MLH1 protein deletion and tumor size,degree of differentiation,lymph node metastasis and TNM stage(P ? 0.05);MSH2 protein deletion was associated with the age of onset,tumor size,lymph node metastasis,TNM stage There was a statistically significant difference between the two groups and the vascular invasion group(P ? 0.05);MSH6 protein deletion was statistically significant compared with the age of onset,tumor size,lymph node metastasis,distant metastasis,TNM stage,nerve invasion and vascular invasion Differences(P ? 0.05);PMS2 protein deletion was statistically different between patients with age at onset,tumor size,degree of differentiation,lymph node metastasis,TNM stage,and nerve invasion(P ? 0.05).The tumor size,degree of differentiation,lymph node metastasis,distant metastasis,TNM stage,nerve invasion and vascular invasion were statistically different(P ? 0.05).1.2.Among the 491 patients with complete follow-up data.69 patients with dMMR colorectal cancer had a 3-year overall survival rate of 71.0%;422 patients with pMMR colorectal cancer had a 3-year overall survival rate of 57.11%;single factor analysis showed that the 3-year overall survival rate and MMR function status of patients There was a statistically significant difference between tumor location,general type,depth of invasion,and nerve invasion(P ? 0.05).Cox multivariate analysis showed that MMR function status,tumor growth position,and nerve invasion were closely related to the 3-year overall survival rate Correlation(P ? 0.05)..2.Among the 491 patients with complete follow-up data.69 patients with dMMR colorectal cancer had a 3-year overall survival rate of 71.0%;422 patients with pMMR colorectal cancer had a 3-year overall survival rate of 57.11%;univariate analysis showed that the 3-year overall survival rate and MMR function status There was a statistically significant difference between tumor location,general type,depth of invasion,and nerve invasion(P ? 0.05).Cox multivariate analysis showed that MMR function status,tumor growth position,and nerve invasion were closely related to the 3-year overall survival rate Related(P ? 0.05).Conclusion:1.1.The loss of mismatch repair proteins MLH1 and PMS2 is the main risk factor affecting tumor lymph node metastasis;MMR functional status is closely related to tumor size,degree of differentiation,neural invasion and vascular invasion.2.2.The 3-year prognosis of patients with dMMR colorectal cancer is better than that of patients with pMMR colorectal cancer,and there are significant differences in statistical analysis.MMR functional status can be used as a biomarker to predict the overall prognosis of colorectal cancer patients. |
PDF Full Text Request