Study On The Correlation Between Macrophage Migration Inhibitory Factor And Hypertension

ObjectiveHypertension is one of the most common cardiovascular diseases,with an annual death toll of 9 million worldwide due to hypertension and related complications.The incidence rate is on the rise year by year.Involving inflammation and endothelial dysfunction,the pathogenesis of hypertension is complex.Macrophage migration inhibitor(MIF)is a factor related to inflammatory diseases.It plays a pro-inflammatory role in vascular endothelial dysfunction and thus participates in the process of atherosclerosis,in which,hypertension is a risk factor.This study mainly discussed the correlation between plasma MIF level and hypertension;and whether plasma MIF level can be used as an independent predictor of hypertension risk factors.Methods187 patients with hypertension and 121 patients without hypertension hospitalized in a department of cardiology in Shaanxi Provincial People's Hospital from November 2017 to November 2019,all of 256 patients with from 30 to 80 years old,were elected as research objects.Venous blood was collected from all enrolled patients in the morning on the second day after admission,biochemical indicators were detected,and plasma MIF concentration was detected by ELISA.Statistical methods were used to explore the relationship between plasma MIF and hypertension.The expression levels of plasma MIF in hypertensive patients and non-hypertensive patients were analyzed,and Spearman was used to analyze the relationship between MIF and systolic,diastolic and mean arterial pressure.Whether plasma MIF level can be used as an independent predictor of hypertension risk factors by Logistic regression.The sensitivity and specificity of area analysis predictors under ROC curve were calculated.Results1.In this study,plasma MIF level was significantly higher in hypertensive patients than in non-hypertensive patients(P < 0.001).The relationship between plasma MIF,systolic blood pressure,diastolic blood pressure and mean arterial pressure was further analyzed.The mean systolic blood pressure,diastolic blood pressure,and mean arterial pressure were 130.78±19.93 mmHg,79.33±11.90 mmHg,96.68±13.43 mmHg,and the mean of mean was 66.00±17.76ng/ml.Plasma MIF was found to be related with systolic,diastolic and mean arterial pressures(P<0.001).2.Logistic regression model was used to research the relationship between plasma MIF and hypertension.After adjusting for confounding factors,the results showed that plasma MIF was significantly correlated with hypertension(P < 0.001).The level of MIF in plasma was divided into three points from low to high.After the unadjusted confound-factor and the adjusted confound-factor,as the results showed that,plasma MIF level in the third score was always significantly correlated with hypertension(P < 0.001),and the risk of hypertension in the third score was 4.55 times,4.55 times,4.91 times and 4.38 times as high as that in the first score,respectively(95% CI was 2.47-8.40,2.39-8.67,2.54-9.48 and2.18-8.81,respectively)according to the Logistic regression model,And this suggests that plasma MIF levels are independent risk factors for hypertension.3.The ROC curve was drawn to find the Cutoff value,and area under ROC curve(AUC)was calculated to be 0.71(P < 0.001),indicating that the plasma MIF level had a good prediction accuracy for the incidence of hypertension.Conclusion1.Plasma MIF levels are associated with hypertension.2.Plasma MIF level is an independent risk factor for hypertension.