Analysis Of The Level Of Chemerin And Its Clinically Related Factors In Infants Of Diabetic Mothers

Objective: The serum chemerin,blood glucose,insulin and blood lipids of neonates in the study group and the control group were detected,and the serum chemerin content of neonates of diabetic mothers and its correlation with clinical related factors were analyzed,so as to explore the influence of the serum chemerin of neonates on various indicators.Methods: 59 newborns of diabetic mothers were selected,among which 16 were in the group with maternal blood glucose control below the standard,and 43 were in the group with maternal blood glucose control at the standard.30 neonates of normal pregnant women were selected as the control group.Basic clinical factors of pregnant mothers and neonates were recorded.Serum chemerin,blood glucose,insulin and blood lipid of neonates in the study group and the control group were detected.The relationship between chemerin levels and related clinical indicators was compared.Results:1.Analysis of clinical perinatal factors: There were no statistically significant differences among the three groups in maternal age,pregnancy week,mode of delivery,body mass index at the end of gestation,sex of the newborn,born days and Apgar score of the newborn(P>0.05),so it's comparable;There were significant differences in neonatal birth mass in the three groups(P<0.05).2.Comparison of cord blood and venous blood chemokine content: There was no statistically significant difference in serum chemerin levels between cord blood and venous blood groups(P>0.05).3.Analysis of serum chemerin levels of neonates with different maternal blood glucose control: The difference of serum chemerin levels in the group with maternal blood glucose control below the standard,the group with maternal blood glucose control at the standard and the control group was statistically significant(P<0.05);4.Comparison of blood sugar,duration of hypoglycemia,insulin resistance index,and lipid levels of three groups of newborns: Newborn blood sugar,hypoglycemia duration,insulin resistance,total cholesterol and triglyceride levels in the pregnant mother blood sugar control substandard group,pregnant mother blood sugar control standard group,control group,the difference was statistically significant(P<0.05).5.Correlation analysis of the levels of chemerin in infants of diabetic mothers and various indicators: According to Pearson correlation analysis,the serum chemerin levels of newborns in the study group showed negative correlation with blood sugar levels(P<0.05);It was positively correlated with birth weight,hypoglycemia duration,insulin resistance index,total cholesterol and triglyceride levels(P<0.05).Conclusions:1.There was no difference in the expression level of chemerin in cord blood and venous blood,so the content of cord blood chemerin can better reflect the level of venous blood chemerin;2.The serum chemerin content of IDM was negatively correlated with fasting blood glucose and positively correlated with the duration of hypoglycemia.Early monitoring of chemerin content may be of certain value in estimating the occurrence and duration of hypoglycemia in newborns;3.The serum chemerin content of IDM was positively correlated with birth mass and blood lipid;4.The serum chemokine content of IDM was positively correlated with insulin resistance,suggesting that IDM had insulin resistance;5.Good control of blood sugar during pregnancy can reduce the production of chemerin.