| Objective:To analyze the correlation of transcutaneous bilirubin(TCB)and total Serum Bilirubin(TSB)in neonatal jaundice.Method:Two hundred and thirty-six neonatal jaundice neonates hospitalized in the Neonatal intensive care unit(NICU)of Kuancheng county hospital were enrolled,assigned into high-risk groups(n=74),intermediate-risk group(n = 91)and low-risk group(n=71)according to serum bilirubin level.JM-103 detector was used for TCB detection,and blood samples were tested for bilirubin(TSB)within 30 minutes after TCB detection.The results and correlation of TCB and TSB before and after phototherapy were analyzed.Data analysis was performed using SPSS22.0 software.Results:1.General information: One hundred thirteen were males and 123 were females,with an average gestational week of 38.2±1.4 weeks,and average birth weight was 2743.5±403.5g.There were no statistical differences in gender,delivery,and incidence of neonatal asphyxia among different groups(P>0.05).The Apgar scores of gestational age,phototherapy initiation time,and 1min at birth in the high-risk group were significantly lower than those in the intermediate and low-risk group(P<0.05),and the duration of phototherapy was significantly longer than that in the intermediate and low-risk group(P<0.05).2.The mean values of TSB in high-risk group,intermediate-risk group and low-risk group before phototherapy were 15.1±3.2 mg/dl,13.2±3.5 mg/ dl and 12.1±2.9 mg/dl.The average of the frontal,chest and frontal thorax in the high-risk group was significantly lower than the TSB(P<0.05).There was no statistical difference in the value of the frontal,chest,and frontal thorax of TSB between intermediate-risk group and low-risk group(P>0.05).Correlation analysis results showed that the correlation between TCB and TSB in the high-risk group before the phototherapy was the lowest(r=0.781,P<0.001);the mean frontal chest TCB in the intermediate-risk group had the highest correlation with TSB(r = 0.911,P<0.001);The correlation coefficient of mean frontal chest TCB and TSB of low-risk group was 0.899(P<0.001).3.The mean values of TSB in high-risk group,intermediate-risk group and low-risk group 24 h after phototherapy were 12.1±2.4 mg/dl,11.2±2.8 mg/dl and 10.4±2.6 mg/dl.The chest TCB in the high-risk group was significantly higher than that of TSB(P<0.05).The mean values of chest TCB and mean frontal chest TCB of intermediate-risk group were significantly higher than TSB(P>0.05).In the low-risk group,the frontal TCB,chest TCB,and mean TCB value of frontal and chest were not statistically different with TSB(P>0.05).Correlation analysis showed that the correlation between frontal TCB and TSB of the high-risk group was the lowest 24 h after phototherapy(r=0.615,P<0.001);the correlation between the frontal TCB and TSB in the low-risk group was the highest(r=0.896,P<0.001);the correlation coefficient between the frontal TCB and TSB in the intermediate-risk group was 0.842(P<0.001).4.TCB and TSB tests were performed in 110 cases at 24 h to 7d(before phototherapy)(early group),and 126 cases were tested at TCB and TSB(late group)after 7d(before phototherapy).There was no statistical difference between the average TCB and TSB of the frontal,chest,and frontal chest in the early group(P>0.05).The TCB of the frontal,chest,and frontal chest in the late group were significantly lower than TSB(P< 0.05).Conclusions:1.TCB can be used as an early screening and diagnosis method for neonatal hyperbilirubinemia,which has a good correlation with TSB before phototherapy;2.TCB can be used as a reference for phototherapy effect evaluation in neonatal hyperbilirubinemia;3.The test results of TCB in low and intermediate-risk neonates have high consistency with TSB,but the test results in high-risk neonates are relatively inconsistent with TSB,which need to be adjusted to improve the diagnostic accuracy.4.Age may be an important factor in the accuracy of TCB detection.TCB measurements within 7 days are more closer to TSB. |
