Meta Analysis Of LAMA/LABA Combined Therapy As Initial Maintenance Therapy For COPD

Objective : Meta analysis was used to evaluate the efficacy and safety of LAMA/LABA combined therapy as initial maintenance therapy for COPD.Methods: using the retrieval method to search the computer database: Wanfang,VIP,CNKI,Pubmed,Cochrane,Web of Science,and the quality of the included randomized controlled trials was evaluated,the data were analyzed by Rev Man5.3.Results: a total of 11 RCT literatures were included,with a total number of 18809.Meta analysis showed that 1-hour post-dose FEV1 from baseline,LAMA/LABA was significantly increased in both LAMA and LABA(MD 0.10(95%CI 0.08,0.12)),and the difference was statistically significant(P<0.05).The difference between LAMA/LABA vs LAMA(MD 0.05(95%CI 0.03,0.06),LAMA/LABA vs LABA(MD 0.08(95%CI 0.06,0.09))and LAMA/LABA vs LABA/ICS(MD 0.07(95%CI 0.05,0.09))is statistically significant(P < 0.05).In terms of safety,LAMA/LABA,LAMA,LABA,LABA/ICS,and placebo were compared in terms of total adverse events,serious adverse events,cardiovascular adverse events,adverse events leading to withdrawal from the trial,and death,the difference was not statistically significant(P > 0.05).Conclusion: LAMA/LABA combined therapy,as initial maintenance therapy for COPD,can significantly improve lung function without increasing the probability of adverse events,and has the same safety as one single bronchodilator.