Correlation Analysis Between Telomere Length And Coronary Heart Disease And Its Plaque Stability

Objective:To explore the relationship between Leukocyte Telomere Length(LTL)in peripheral blood and Coronary Heart Disease(CHD)and its classification,the relationship between Telomere Length and the degree of coronary stenosis,the relationship between Telomere Length and Coronary plaque properties,and the corresponding influencing factors.Methods:112 patients diagnosed with CHD after the first Coronary Angiography(CAG)in our Hospital from August 2018 to August 2019 were selected as the study subjects.All CHD patients were divided into four subgroups according to CHD types: stable angina pectoris(SAP)group,unstable angina(UA)group,ST-segment elevation myocardial infarction(STEMI)group,non-ST-segment elevation myocardial infarction(NSTEMI)group.Meanwhile,75 patients received CAG and excluding CHD at the same time period were selected as a control subject.Collect two groups of patients with clinical data,inspection index,the results of CAG,the results of coronary intravascular ultrasound(IVUS),Gensini score,Telomere length.To analyze differences of peripheral blood LTL in each group,and the factors influencing LTL.Results:Peripheral blood LTL in the CHD group and the non-CHD group were 1.77±0.80 and 2.07±1.81.LTL in the CHD group was significantly shorter than the non-CHD group.There was a statistical difference between the two groups(P<0.05).LTL of SAP group,UA group,STEMI group and NSTEMI group were respectively 2.00±0.57,2.31±0.99,1.33±0.47 and 1.25±0.52.There were statistically significant differences between SAP group and STEMI group(t=4.841,P=0.000)and NSTEMI group(t=5.068,P=0.000).There were also statistically significant differences between UA group and STEMI group(t=4.610,P=0.000)and NSTEMI group(t=4.729,P=0.000),while there were no statistically significant differences between SAP group and UA group(P=0.135),STEMI group and NSTEMI group(P=0.563).Depending on the Gensini score,there was a statistical difference in LTL between the four subgroups(P<0.05),and the two groups showed a significant negative correlation(r=-0.307,P<0.01).Depending on the results of IVUS,LTL in plaque instability group was shorter than that in plaque stability group(2.32±0.70 vs 1.31±2.22,P=0.000).Age was negatively correlated with LTL in the CHD group(r=-0.205,P=0.002)and the non-CHD group(r=-0.317,P=0.000),but it was only statistically significant in the 45-60 age group(P=0.001).According to partial correlation analysis results,LTL in CHD group was significantly negatively correlated with hypertension(r=-0.303,P=0.043)and Gensini score(r=-0.709,P=0.000).Multiple linear regression analysis showed that peripheral blood LTL in the CHD group was correlated with age(B=-0.222,P=0.022),prevalence of hypertension(B=-0.297,P=0.046),and non-CHD peripheral blood LTL was not only correlated with age(B=-0.421,P=0.000),but also negatively correlated with smoking history(B=-0.029,P=0.000)and HDL(B=-0.278,P=0.012).Conclusion:Be compared to non-CHD patients,peripheral blood LTL is shorter in CHD patients,and short telomere length may be clinically indicative of acute myocardial infarction(AMI).In patients with coronary heart disease,peripheral blood LTL will shorten with the increase of coronary artery stenosis,and the instability of coronary artery plaques is also one of the factors leading to the shortening of LTL.For CHD patients,aging and hypertension may be the principal factors leading to the shortening of peripheral blood LTL.