Relationship Between Frailty And Metabolic Syndrome In Elderly Patients With Chronic Multimorbidity

Objectives To investigate the correlation between frailty and metabolic syndrome in elderly hospitalized patients with chronic comorbidities.Methods In the department of geriatrics,affiliated hospital of north China university of science and technology,from December 2018 to July 2019,hospitalized patients aged ? 60 years and suffering from two or more chronic diseases were selected as the study subjects.According to Fried frailty score,the study subjects were divided into 58 patients in the frailty group(case group)and 67 patients in the non-frailty group(control group).In the case group,29 cases were male(50%)and 29 cases were female(50%),with an average age of 77±8.33 years.The control group included 41 males(61.2%)and 26 females(38.8%),with an average age of 70±6.41 years.The subjects were surveyed by questionnaire and clinical data were collected,including gender,age,height,weight,abdominal circumference,educational level,living alone,fasting blood glucose,triglyceride,high-density lipoprotein,chronic disease status,amount of medication,etc.All data were set up in a database,statistical software SPSS 22.0 was used for statistical analysis,and the main indicators were tested for normality.The measurement data conforming to normal distribution were expressed as "mean ± standard deviation",and independent sample t test was used for comparison between groups.Percentages were calculated from counting data,and chi-square test was used for comparison between groups.The relationship between frailty and metabolic syndrome was analyzed by using single factor analysis and multi-factor logistics regression analysis.Results 1 Compared the general data of the two groups,the mean age of the patients in the frailty group was greater than that of the control group,and the difference between the two groups was statistically significant(P<0.05).The proportion of females was slightly higher than that of the control group,but the difference was not statistically significant(P>0.05).The frailty group had higher BMI,medication quantity and solitary status than the control group,with statistically significant differences(P<0.05).The education level of frailty patients was lower than that of the control group,and the difference was statistically significant(P<0.05).2 According to the analysis of chronic diseases in the two groups,the proportion of chronic obstructive pulmonary disease and chronic heart failure in the frailty group was higher than that in the non-frailty group,and the difference was statistically significant(P<0.05).3 The comparison of the incidence of geriatric syndrome between the two groups showed that the proportion of visual impairment,chronic pain,malnutrition,poor sleep quality and high risk of falls in the fattening group was higher than that in thecontrol group,and the difference was statistically significant(P<0.05).4 Univariate analysis of the relationship between frailty and metabolic syndrome showed that frailty was related to metabolic syndrome,with an OR value of 2.250.The OR values were 2.776,2.415,2.400 and 2.190,respectively,and were not correlated with high triglyceride(P>0.05).5 Two groups of patients with weak and multi-factor analysis showed that metabolic syndrome in ruled out age,culture level,BMI,solitary,visual impairment,malnutrition,chronic pain,fall in the poor quality of sleep,high risk,the amount,chronic obstructive pulmonary disease,chronic heart failure after confounding factors,weak relationship with metabolic syndrome still have statistical significance(P<0.05),and in many influence factors,the relationship between second only to malnutrition,OR a value of 2.869,shows that combination of the metabolic syndrome is the cause of elderly chronic disease occurring weak total important risk factors.At the same time,the correlation analysis of frailty with obesity,low HDL,hypertension and hyperglycemia in metabolic syndrome showed that metabolic syndrome was positively correlated with frailty Conclusions 1 Frailty was significantly correlated with metabolic syndrome.Elderly chronic comorbid patients with metabolic syndrome had an increased risk of frailty,and frailty was positively correlated with obesity,low HDL,hypertension and hyperglycemia.2 Elderly patients with chronic comorbidities have a high incidence of frailty.Compared with non-frailty patients,frailty patients are older,less educated,more medicated,higher BMI,higher solitary status,malnutrition,higher risk of falls,and higher incidence of chronic heart failure.Figure 0;Table 13;Reference 158...