Correlation Between Non-high-density Lipoprotein/high-density Lipoprotein Cholesterol And Type 2 Diabetic Macroangiopathy

Objectives To analyze the relationship between non-HDL-C/HDL-C and type 2 diabetic macroangiopathy.To provide scientific basis for the early diagnosisand prevention of type 2 diabetic macroangiopathy.Methods 208 patients with T2 DM who met the 1999 WHO diabetes diagnostic criteria were admitted to the Department of Endocrinology in the North China University of Science and Technology Affiliated Hospital from December 2017 to October 2019.According to whether to combine with macrovascular disease,divided into type 2 diabetes mellitus with macrovascular disease group of 100 cases and simple diabetes group of 108 cases.Compare gender,age,duration of diabetes,systolic blood pressure(SBP),diastolic blood pressure(DBP),glycated hemoglobin(Hb A1c),fasting blood glucose(FPG),2h blood glucose(2h PG),fasting Insulin(Fins),2h insulin(2h Fins),fasting C peptide(FC-P),2h C peptide(2h C-P),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),non-high-density lipoprotein cholesterol(non-HDL-C),non-HDL-C/HDL-C,lipoprotein small a(Lp(a)),Apolipoprotein A(apo A),apolipoprotein B(apo B).SPSS 17.0 was used for statistical analysis.Normally distributed measurement data were independent t-tests;the relationship between exposure factors and disease was measured using ?2 test;non-normally distributed measurement data were analyzed using Wilcoxon rank sum test;multivariate analysis was performed using non-condition Logistic regression model,P<0.05 was statistically significant.Results 1 Comparison of gender,age,and course of disease composition between the two groups,the proportion of women with type 2 diabetes combined with macroangiopathy was greater than that of the simple diabetes group,and the age and duration of diabetes were significantly greater than those of the simple diabetes group,the differences were statistically significant(P<0.05).2 The levels of SBP,Hb A1 c,FPG,TC,LDL-C,non-HDL-C,non-HDL-C/HDL-C in the two groups,the type 2 diabetes combined with macroangiopathy were higher than those in the simple diabetes group.There was statistical significance(P<0.05).3 There were no significant differences in the levels of DBP,2h PG,Fins,2h Fins,FC-P,2h C-P,TG,HDL-C,Lp(a),apo A,and apo B between the two groups(P>0.05).4 Using LDL-C mean 3.17 mmol/L,non-HDL-C mean 3.82 mmol/L,non-HDL-C/HDL-C mean 3.29 as the cut-off value for exposure analysis.The exposure rates were higher than those in the simple diabetes group,and the difference was statistically significant(P<0.05).5 With or without macrovascular disease as the dependent variable,LDL-C,non-HDL-C,non-HDL-C/HDL-C,and incomparable factors(gender,disease duration,age,SBP,Hb A1 c,FPG,TC)as independent variables.Unconditional Logistic regression analysis shows that after controlling for less comparable factors,non-HDL-C/HDL-C is still a risk of major vascular disease in patients with type 2 diabetes.As non-HDL-C/HDL-C rises,the risk increases.Conclusions 1 Non-HDL-C/HDL-C is closely related to type 2 diabetes with macrovascular disease,non-HDL-C/HDL-C increases,and the risk of macrovascular disease increases.2 Non-HDL-C/HDL-C is more closely related to type 2 diabetic macroangiopathy than LDL-C and non-HDL-C.Figure0;Table10;Reference 167...