The Etiology Of Influenza Co-infection In Beijing From 2016 To 2018

Background: Co-infection of influenza virus with other pathogens is an important reason for the high incidence and high mortality of community-acquired pneumonia.The lack of targeted early-stage medications for community-acquired pneumonia has led to prolonged disease duration,increased treatment costs,and increased bacterial resistance rates.Understanding the distribution characteristics of community-acquired pneumonia-associated co-infectious pathogens can guide clinical rational drug use,as well as prevent and control the occurrence and epidemic of the epidemic in a targeted manner and reduce social burden.Objective: To conduct a multi-pathogen test on community-acquired pneumonia samples infected with influenza virus in Beijing from 2016 to 2018,and to further analyze the pathogenic spectrum and rules of influenza virus co-infection in Beijing to provide community prevention for community-acquired pneumonia in Beijing And provide theoretical basis for clinical diagnosis and treatment.Methods: Respiratory tract samples such as nasopharyngeal swabs,sputum,bronchoalveolar lavage fluid,and thoracentesis were collected from 307 community-acquired pneumonia patients with positive influenza virus nucleic acid tests in Beijing from 2016 to 2018.Real-time quantitative fluorescence PCR laboratory detection of a variety of respiratory pathogens.The test results were grouped according to different factors,SPSS 21.0 software was used,and the c2 test was used for statistical analysis of the count results.Results: In all 307 samples,15 of 23 respiratory pathogens were detected.Including 272 cases of influenza A virus,accounting for 88.60% of all samples;followed by 92 cases of methicillin-resistant Staphylococcus aureus,accounting for 29.97% of all samples;65 cases of influenza B virus positive,accounting for 21.17 of all samples %.The proportion of influenza virus co-infected with other pathogens(68.08%)was significantly higher than that of influenza virus alone(31.92%).In the co-infected samples,the highest co-infection of 6 pathogens was detected,and the co-infection of influenza virus and bacteria accounted for the majority(75.60%).Older people are more prone to co-infection and are more likely to progress to severe illness.The positive rates of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa were significantly higher in the elderly and critical populations.The incidence of influenza virus coinfection,the number of pathogens,and the distribution of pathogen positive rates did not differ significantly between different genders.During 2016-2018,most of the community-acquired pneumonia infected with influenza virus in Beijing occurred in spring and winter(60%),and less frequently in summer and autumn(40%).Conclusion: Among the community-acquired pneumonia patients with influenza virus positive in Beijing from 2016 to 2018,the infection rate of influenza A virus was significantly higher than that of influenza B virus,and the proportion of co-infection was significantly higher than that of influenza virus infection alone proportion.Compared with other respiratory viruses,the co-infection of influenza viruses and bacteria is more common,mainly methicillin-resistant Staphylococcus aureus,followed by Streptococcus pneumoniae and Klebsiella pneumoniae.This study provides data support for preventing and guiding the development of clinical treatment strategies and drug screening for patients with influenza-acquired pneumonia.