The Value Of Galectin-3 In The Diagnosis And Severity Assessment Of Acute Coronary Syndrome

Objective Galectin-3 is a novel biomarker related to inflammation and fibrosis.Our purpose was to investigate the value of galectin-3 in the early diagnosis and the severity assessment among acute coronary syndrome(ACS)patients.Methods: From December 2018 to June 2019,we consecutively recruited patients visiting the Emergency Department or hospitalized in the Department of Cardiology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University.The patients were highly suspected of CAD and underwent coronary angiography(CAG).Then 102 patients confirmed as acute coronary syndrome(ACS)were eventually enrolled and set into ACS group.After matching genders and ages,55 patients were diagnosed with other CAD such as stable angina were brought into the non-ACS group.The severity of coronary artery lesions was evaluated by the Gensini score and number of vascular involved according to coronary angiography(CAG).All statistical analyses were performed with SPSS software V.23.0 and Graph Pad Prism V.7.0.Serum galectin-3 were detected by chemiluminescence microparticle immunoassay(CMIA).The Diagnostic and severity prediction values of biomarkers alone or combined for ACS patients were conducted by calculating area under the curve(AUC)of receiver operator characteristics(ROC)with Med Calc 11.4.2.0.Correlation analysis of galectin-3 with clinical and biochemical parameters was performed with nonparametric Spearman's rank correlation test.The multivariate analysis of investigated parameters was carried out using logistic regression analysis.Results: 1.The average age of the study patients was 64.08 years old,and male is the majority of gender(68.2%).ACS patients had higher levels of Tn I,galectin-3,and CK-MB,compared to non-ACS patients.The LVEF levels of ACS patients were lower than non-ACS patients.The galectin-3 levels of study patients was significantly higher than healthy people(P<0.05).2.The power of Tn I was better than galectin-3 in diagnosing ACS,but the AUC of them did not show a significant difference.A significant difference of AUC was found for diagnosing ACS between the combination of galectin-3 with Tn I and independent of them.3.The nonparametric Spearman's rank correlation test suggested that there were signicant correlations between galectin-3 and coronary artery disease parameters: Gensini score(r = 0.341,P < 0.001)and number of involved vessels(r = 0.257,P = 0.01).4.Age,Tn I and CK-MB were also found a positive correlation with serum galectin-3 levels,and e GFR were found a negative correlation with serum galectin-3 levels.Nevertheless,there was no significant correlation found between serum galectin-3 levels and LVEF.5.Logistic regression analysis revealed that high value of serum galectin-3 levels at baseline(?18.63ng/m L)remained an independent predictor for ACS after adjustment for LVEF,heart rats,FBG,HDL,hypertension,and smoking.Conclusion: 1.Galectin-3 played a vital role in diagnosis of ACS,and combined measurement of both serum galectin-3 and Tn I could enhance the diagnostic accuracy;2.Serum galectin-3 levels had a good correlation with Gensini score,it also worked in predicting the severity of coronary artery disease.3.High levels of galectin-3 might be an independent risk factor for the occurrence of ACS.