Clinical Data And Survival Follow-up Study Of Synchronous Colorectal Cancers

Objective: To explore the clinical characteristics and survival prognosis of synchronous colorectal cancers.Methods: This article retrieved the clinical data of 3547 patients with primary colorectal cancer who were seen at the Fourth Hospital of Hebei Medical University from January 2017 to December 2019.Retrospective review was performed on 79 patients with synchronous colorectal cancers.At the same time,The study used a randomized controlled method to match the clinical data of 150 patients with solitary colorectal cancer.All cases included in the study were compared and analyzed from the aspects of demographic characteristics,basic clinical data,surgical and pathological data,survival and prognosis-related data,and statistical analysis was performed using SPSS 23.0.Results: Among the 3,547 patients with primary colorectal cancer,79 patients diagnosed with synchronous colorectal cancers,and the incidence was 2.23%.There were 60 males and 19 females with synchronous colorectal cancers.The average age of onset was(61.23 ± 12.59)years.Compared with solitary colorectal cancer at the same time,patients with synchronous colorectal cancers have the following characteristics: higher incidence in men(P = 0.012),more patients with anemia(P <0.001),hypoproteinemia(P = 0.001),and colorectal adenoma(P <0.001),and more patients were unable to undergo a complete colonoscopy before surgery(P <0.001).The location of synchronous colorectal cancers was different from that of solitary colorectal cancer(P < 0.001),and most in the proximal colon.The mean postoperative hospitalization time of patients with synchronous colorectal cancer undergoing radical surgery was(9.84±3.40)days,which was longer than that of patients with solitary colorectal cancer after radical surgery(P=0.041),and the risk of intestinal obstruction was higher(P=0.037).At the same time,there were more patients with high microsatellite instability(MSI-H)in Synchronous colorectal cancers(P < 0.001).Patients were followed up by telephone.The median follow-up time was 12 months.There was no significant difference in disease-free survival(DFS)between the two groups(P = 0.577).Conclusions:1.Synchronous colorectal cancers patients accounted for 2.23% of all primary colorectal cancer patients,which should not be ignored in clinical practice.2.Patients with synchronous colorectal cancers are more common in male patients,and often associated with anemia,hypoproteinemia,colorectal polyps.In more patients,complete colonoscopy is not feasible before surgery.3.Patients with synchronous colorectal cancers undergoing radical surgery have longer average postoperative hospitalization and higher risk of postoperative intestinal obstruction.We should pay attention to the perioperative management of these patients.4.There was no significant difference in DFS between patients with synchronous colorectal cancers and solitary colorectal cancer in 3 years.