The Study Of Relationship Between Subjective And Objective Evaluation Of Psychological Stress And Nonalcoholic Fatty Liver Disease Based On Transdermal Optical Imaging Technology

Objective:To evaluate the subjective and objective psychological stress status of non-alcoholic fatty liver(NAFLD)patients and normal people,and to conduct further comparative analysis of factors that may affect the incidence of NAFLD.And to compare various data of NAFLD patients with different subjective and objective psychological pressure gradients in order to obtain the relationship between subjective and objective stress and the occurrence and severity of NAFLD.Methods:A total of 96 patients who were newly diagnosed as NAFLD in our outpatient clinic from June 2019 to January 2020 were selected as the study group,and 98non-NAFLD patients matched with gender and age in our hospital physical examination center at the same time were used as the control group.Measured objective psychological stress score(ASI value)by using psychological stress assessment software(Anura V2.0.6)based on Transdermal optical imaging technology;used Chinese version of Perceived Psychological Stress Scale(CPSS)to evaluate subjective Psychological stress score(CPSS value)and compared.Then Combined with other factors that may affect the incidence of NAFLD for further comparative analysis.The NAFLD patient group was further grouped according to the ASI value and the CPSS value: the group with greater objective psychological stress(group A,ASI value ≥ 4,n = 36)and the group with lesser objective psychological stress(group B,ASI value <4,n = 60);Greater subjective psychological stress group(group C,CPSS value ≥ 26,n = 49)and lesser subjective psychological stress group(group D,CPSS value <26,n = 47).Collect various data(general conditions,clinical indicators,behavioral data)of NAFLD patients for comparison between different subjective and objective psychological pressure gradient groups.Results:Through statistical analysis,there was no significant difference in general information between the study group and the control group(P> 0.05).Among the 96 NAFLD patients,the ASI value was 3.88 ± 0.49,the proportion of people with ASI value ≥ 4 was 37.5%,the CPSS value was 26.2 ± 4.5,and the proportion of people with CPSS value ≥ 26 was 51.0%;98 non-NAFLD patients,the ASI value was 3.47 ± 0.48,the proportion of people with ASI value ≥ 4 was 13.2%,the CPSS value was 23.8 ± 3.3,and the proportion of people with CPSS value ≥ 26 was 35.7%.Compared with non-NAFLD patients(control group),patients with NAFLD(study group)have a higher ASI value,a higher proportion of people with a higher objective psychological stress value,a higher CPSS value,and a higher proportion of people with a higher subjective psychological stress value,all these differences are significant statistically(P <0.05).After multivariate analysis of all factors that may affect the onset of NAFLD we found that higher ASI values(OR 2.76)and higher CPSS values(OR 2.54)were independent risk factors affecting the incidence of NAFLD.Other independent risk factors affecting the incidence of NAFLD are elevated ALT,elevated AST,elevated γ-GT,elevated ALP,elevated TC,elevated TG,reduced HDL-c,elevated LDL-c,and higher BMI,smoking history,eating habits favoring meat.And there was no significant correlation between the ASI value and the CPSS value(P> 0.05).Among the relevant indicators,Group A and Group B have significant differencesin ALT,AST,γ-GT,ALP,TC,TG,HDL-c,LDL-c,BMI,Fibroscan CAP and E values(P <0.05).Except for HDL-c,the value of group B is greater than group A,and the remaining indicators of group A are greater than group B;while in FPG,ALB,age,gender,education,whether smoking,whether to exercise,whether to stay up late,whether social relationships are harmonious,and dietary habits,there are no significant differences.There were significant differences between group C and group D in terms of BMI,Fibroscan CAP value and E value,smoking,persistent exercise,staying up late,eating habits(P <0.05).Compared with group D,group C’s BMI and Fibroscan CAP and E values are larger,and they are less likely to keep exercising,they are more likely to smoke and stay up late,and they are more likely to eat meet.While in ALT,AST,γ-GT,ALP,TC,TG,HDL-c,LDL-c,FPG,ALB,age,gender,academic qualifications,whether social relations are harmonious,there is no significant difference.Conclusion:1.NAFLD patients have higher subjective and objective psychological pressure than normal people.Excessive subjective psychological pressure and objective psychological pressure are both independent risk factors for the onset of NAFLD,and are related to the occurrence and development of NAFLD.2.The assessment of objective psychological stress in NAFLD patients based on the application of Transdermal optical imaging technology is more relevant to clinical indicators than the traditional psychological scale subjective psychological stress assessment.Excessive objective psychological pressure is related to the abnormal activation of the hypothalamus-pituitary-adrenal axis and the sympathetic nervous system,which leads to abnormal lipid metabolism,thereby promoting the occurrence and development of NAFLD.3.The subjective stress assessment of traditional psychological scale is related to the lifestyle of NAFLD patients.Excessive subjective psychological pressure can easily lead to an unhealthy lifestyle and promote the occurrence and development of NAFLD.