Performance Simulation Analysis Of Artificial Bone Scaffold Based On TPMS Unit

Bone tissue engineering is an effective method for the treatment of defective bone tissue.Its core idea is to assist the bone repair process by using biological scaffolds with similar properties to the original bone tissue as temporary substitutes.However,the cycle of bone reconstruction is long,so it is a waste of manpower and material resources to only rely on in vivo test for relevant research.Therefore,it is of great significance to conduct relevant research through numerical simulation.In this paper,the properties of Triply Minimal Surfaces(TPMS)as biological scaffolds were analyzed,including structural properties,biomechanical properties,fluid properties,degradation and bone remodeling.First,P unit and I-WP unit are selected from TPMS to establish a unit model through parametric modeling and Geomagic is used to build the unit.On this basis,the influence of configuration parameters(S,K)and thickness on porosity and specific surface area of the two units is completed.In biomechanical properties,under different configuration parameters of P cells and I-WP unit under axial load and tangential load of elastic modulus and shear modulus are studied,and did the normalized processing,through data fitting to further the normalization of two units of elastic modulus and the normalized shear modulus and the relationship between volume fraction,found P main deformation state has a lot to contact and the change of the configuration parameters.In terms of flow performance,based on Darcy's law completed under different configuration parameters P unit and I-WP cell permeability analysis,and according to the Bernoulli equation analysis of the flow field inside the bracket of the velocity field and pressure field distribution,uniform from cells,tissue fluid permeability and cell growth mechanics environment to evaluate the flow property of every unit.In terms of the degradation of scaffolds and the reconstruction of bone cells,the change rules of the average molecular weight and elastic modulus of P units and I-WP units in the process of degradation,as well as the change rules of bone mineral density and new bone elastic modulus in the process of bone reconstruction were analyzed through the degradation and bone reconstruction theory.The study found that the maximum strain of unit P structure was significantly affected by the configuration parameters during degradation.During bone reconstruction,the surface osteocytes of unit P were significantly affected by stress stimulation,and the surface osteocytes of I-WP unit were significantly affected by permeability at the early growth stage and stress stimulation at the later growth stage.