The Research On Physical Properties, Biocompatibility And Degradation Properties Of The Degradable Polymers Materials

Objective: This research aims to synthesize and select high molecularweight polymer materials with good physical properties and tissuecompatibility which could be used to fabricate bioresorbable cardiovascularstents. It will lay important experimental basis for the fabrication of newbioresorbable cardiovascular stents and the development of coronary heartdisease therapy in the future.Content： Three kinds of polymer materials films of Poly-l-lacticacid(PLLA),Poly-l-lactic acid-co-trimethylene carbonate(PLLA-TMC), Poly-l-lactic acid-co-trimethylene carbonate-co-G-lycolide(PLLA/TMC/GA）with10mm10mm0.4mm, respectively，were prepared and Physical properties,tissue compatibility and biodegradable behaviors of polymer materials invest-igated. Through this approach, we can select the best polymer materials tofabricate the bioresorbable cardiovascular stents.Methods: Tensile tests and differentia scanning calorimetry were carriedout to evaluate the mechanical and heat property of these polymers. All kindsof polymer films were implanted into thesubcutaneous tissue of SD rats. Atdifferent times, we executed SD rats and took the polymer films and their surrounding tissures out. Then we carry out the following experiments as: HEstaining to detect the of the polymer materials; Weight loss rate and thermalperformance changes to determinate degradation ability.Results and Conclusion: PLLA/TMC/GA has good tissue compatibilityand bio-degradable behaviors and can be used to fabricate fully biodegradablevascular scaffolds.