| ObjectiveSarcopenia is a major disease that affects the quality of life of elderly peopleas the aging of our country becomes more serious.Previous studies have focused on the effects of sarcopenia on skeletal muscle,but have not conducted research in other areas such as myocardium.There is little research on sarcopenia and myocardial mass at home and abroad.This study limited the conditions of research objects to patients who had chronic heart failure,which can rule out the differences in the effects of chronic heart failure on heart disease,and studied the effects of sarcopenia on myocardial quality more specifically.MethodsThis trial design included 120 eligible patients who were admitted to the Department of Geriatrics of the Affiliated Hospital of Qingdao University from January 1,2018 to October 30,2019 as study subjects.According to the diagnostic criteria of The Asian Sarcopenia Working Group(AWGS),the patients were placed into two groups,arcopenia group(43 cases)and non-sarcoidism group(77 cases).The gender and age of the selected patients were recorded,and the weight and height of the patients were measured to calculate the body mass index(BMI).The main past medical history and medication history(such as diabetes,hypertension,old myocardial infarction,etc.)was collected,and serological indicators such as type Bnatriuretic peptide(BNP)and high-sensitivity troponin were examined.Two groups of patients underwent echocardiography,recorded the results of conventional echocardiography,and calculated the left ventricular myocardial mass(LVM)and left ventricular myocardial mass index(LVMI).The data was sorted using Excel2016,and statistical analysis was performed using SPSS24.0 software.The count data was expressed by the number of cases and percentages,and the measurement data was expressed by X±S.The measurement data of the two groups were compared using the independent sample t-test,and the comparison of the two groups of counting data was performed using the?~2 test.The two groups were compared for age,BMI,BNP,LVEF,LVM,and LVMI.The difference was statistically significant at P<0.05.Pearson correlation analysis was used to describe the bivariate correlation.P<0.05 was considered statistically significant.Logistic regression test was used to analyze the relationship.Results1.The 120 subjects included in this study included 69 males(57.5%)and 51females(42.5%),aged 60 to 87 years,with an average age of 74±6.22 years.A ccording to the diagnostic criteria of sarcopenia,there were 43 patients(35.83%)in the sarcopenia group,including 31 males(72.09%)and 12 females(27.91%).Compared with the non-sarcopenia group,the proportion of males in the sarcopenia group was significantly higher than that in the non-sarcopenia group,and the difference was statistically significant(X~2=5.840,P<0.05).There are significant differences in age,weight,and BMI between the sarcopenia group and the non-sarcom a group.Compared with the non-sarcoma group,the average age of the sarcopenia group is generally greater than that of the non-sarcopenia group(76.9±5.9 vs 72.4±5.9),but the body weight(62±6.1 vs 66±5.4)and BMI(21.7±2.1 vs 22.9±1.5)were lower than those in the non-sarcopenia group,and the differences were statistically significant(both P<0.05).However,there was no significant difference in medical history such as hypertension(X~2=0.462,P=0.497),diabetes(X~2=0.047,P=0.829),and old myocardial infarction(X~2=0.014,P=0.907).No statistical significance(both P>0.05).2.The results of comparing the total muscle mass of the two groups showed that the average level of pace,grip strength and skeletal muscle mass(SMI)in the sarcopenia group was lower than that in the non-sclerosis group(0.65±0.08 vs0.88±0.07,18.58±4.53 vs 28.72±5.09,6.05±0.99 vs 8.17±2.3),the difference was statistically significant(P<0.05).3.Compared with the cardiac function indexes of the two groups,the BNP results of the two groups were not significantly different(511.2±592.8 vs 474.49±425.28),and the difference was not statistically significant(P>0.05).In terms of high-sensitivity troponin and LVEF,muscle The level of high-sensitivity troponin in the schizophrenia group was higher than that in the non-sarcoidosis group(0.14±0.26 vs 0.04±0.07),and the LVEF was lower than that in the non-muscular dystrophy group(46.67±9.52 vs 59.06±8.08).Statistical significance(P<0.05).4.Comparison of myocardial mass and myocardial mass index between the two groups.The myocardial mass of the sarcopenia group is generally lower than that of the non-sarcoidosis group(169.55±35.38 vs 206.51±42.86).Decreased(101.81±22.23 vs 119.87±25.31),the difference was statistically significant(P<0.05).5.Correlation analysis of skeletal muscle mass and myocardial mass:skeletal muscle mass and myocardial mass showed a significant positive correlation(r=0.869,P<0.001).Conclusions1.According to the results of the study,it can be concluded that sarcopenia has a significant correlation with age and is more likely to occur in elderly men.The weight and BMI value of sarcopenia patients generally decline,which is related to the previous presence of diabetes,hypertension and old myocardium No history of infarction was involved.2.Comparison of myocardial mass between the two groups:myocardial mass(LVM)and myocardial mass index(LVMI)of sarcopenia patients were significantly lower than those of non-sarcoma group,indicating that sarcopenia can cause myocardial mass decline.3.Sarcopenia can increase hypersensitivity troponin and LVEF decrease to varying degrees.4.Skeletal muscle mass is positively correlated with myocardial mass.The lower the skeletal muscle mass,the more severe sarcoidosis,and the smaller the myocardial mass. |
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