Correlationship Between The Metabolic Syndrome And Adult Urinary Calculi

BackgroundUrinary calculi are common and high incidence of urinary system diseases,no matter in developed countries or developing countries,the incidence rate is increasing year by year.The pathogenesis of urinary calculi is not fully understood.Some studies have found that the metabolic syndrome is one of the risk factors for the formation and recurrence of urinary calculi.The composition of urinary calculi is closely related to the metabolic syndrome.However,there is still a lack of systematic research on metabolic syndrome and urinary calculi and their components,especially the analysis of clinical data.Therefore,we retrospectively analyzed the data of 2,614 cases of urinary calculi hospitalized in the Department of Urology of the Second Affiliated Hospital of Guangzhou Medical University from January 2014 to January 2019,and the analysis report of the composition of 745 calculi.The correlationship between urinary calculi and their components is to provide relevant theoretical basis for further exploring the causes of urinary calculi and their components,formulating diagnostic plans,individualized treatment plans,and targeted prevention and treatment plans.ObjectiveTo explore the correlationship between the metabolic syndrome and adult urinary calculi and their components.Materials and MethodsCollect the names,gender,age,hospitalization number,nationality,ethnicity,occupation,marriage and childbirth history,smoking and alcohol history of patients with urinary calculi hospitalized in the urology department of the Second Affiliated Hospital of Guangzhou Medical University from January 2014 to January 2019Surgery history,time of admission,time of discharge,length of hospitalization,height,weight,BMI,time of admission,systolic blood pressure?SBP?,diastolic blood pressure?DBP?,fasting blood glucose?FBG?,total cholesterol?CHOL?,triglyceride?TG?,High density lipoprotein cholesterol?HDL-C?,low density lipoprotein cholesterol?LDL-C?,sodium?Na⁺?,chlorine?Cl^-?,potassium?K⁺?,calcium(Ca²⁺),phosphorus?P?,Magnesium(Mg²⁺),creatinine?Cr?,uric acid?UA?,urine routine?pH value,urine specific gravity,red blood cell count,white blood cell count,nitrite,bacteria?,hypertension?HBP?and history of type 2 diabetes?T₂DM?,Other concomitant diseases such as medical history,stone location,calculi composition,treatment plan,and discharge status,were screened according to inclusion criteria and exclusion criteria,and included in the database,according to the MetS and NMets group,upper and lower urinary tract stones group,male With the female group,18?28 years old,29?38 years old,39?48 years old,49?58 years old,59?68years old,69 years old and above Each segment group descriptive analysis,analysis of data,to explore the correlationship between the distribution of gender and urinary stones metabolic syndrome and its components,and the contact position distribution difference of distribution of different ages.Results1.2,614 cases met the inclusion criteria,aged 18-92 years,with an average age of 54.77±13.74 years,1,669 male patients,with an average age of 54.62±14.31years,and 945 female patients with an average age of 55.05±12.69 years.There were2,252 cases of upper urinary tract calculi,with an average age of 52.97±12.92 years,1,323 men,with an average age of 52.88±11.69 years,and 929 women,with an average age of 59.24±9.95;362 cases of lower urinary calculi,with an average age of 65.97±13.41 years,There were 345 males with an average age of 66.18±13.06years old and 17 females with an average age of 61.38±18.84 years old.2.MetS group 808 patients with urinary calculi group,average age 56.61±12.04years old,530 men,average age 55.16±12.77 years old,female 278 cases,average age 59.39±10.00 years old;Netet group urinary calculi group 1,806 patients The average age is 53.95±14.37 years old,1139 males,the average age is 54.37±14.98years old,667 females,the average age is 53.24±13.25 years old.3.MetS group patients with urinary calculi age,weight,BMI,SBP,DBP,FBG,CHOL,TG,LDL-C,Ca²⁺,UA,HBP and T₂DM have a higher medical history rate than patients with NMetS urinary calculi,HDL-C and urine The pH value was significantly lower than that in patients with NMetS urinary stones?p<0.05?;there was no significant difference in height,gender,P,Mg²⁺,Cr,and urine specific gravity?p>0.05?.The history of SBP,DBP,FBG,TG,HDL-C,BMI,specific gravity of urine,HBP and T₂DM are independent risk factors for urinary calculi.4.Among patients with upper urinary tract calculi,the number of onset rises with age,peaks at the age of 49?58 years,and declines at the age of 59,the main age of onset is concentrated in the age of 39?68 years;Among patients with urinary calculi,the incidence is positively correlated with age,and the incidence is highest in the age group of 69 years and older;the proportion of patients with upper urinary calculi in the MetS group at 18?38 years old is significantly lower than that in the NMetS group,59?68 years old,The proportion of patients in the MetS group was significantly higher than that in the NMetS group.The proportion of patients with lower urinary calculi in the MetS group was significantly higher than that in the NMetS group?p<0.05?.There was no significant difference in patients with upper and lower urinary calculi in other age groups?p>0.05?;The proportion of men in the18?28 age group and women in the 18?48 age group in the MetS group was significantly smaller than that in the NMetS group,and the proportion of women in the 59 years old and above group was significantly greater than that in the NMet S group?p<0.05?.There was no significant difference?p>0.05?.5.The distribution ratio of right ureteral calculi in male patients with upper urinary calculi in the MetS group was significantly greater than that in the NMetS group,and the distribution ratio of right kidney calculi was significantly smaller than that in the NMetS group?p<0.05?.There was no significant difference between the left urinary system and women?p>0.05?.6.The components of urinary calculi are mainly mixed components,mixed components account for 70.3%,the components of upper urinary calculi are mainly oxalates,the components of lower urinary calculi are mainly urates,and urates are mainly distributed in elderly patients;In patients with upper and lower urinary calculi,anhydrous uric acid in the MetS group was significantly higher than that in the NMetS group,and calcium oxalate-based components were significantly lower than the NMetS group?p<0.05?;female patients in the MetS group calcium oxalate monohydrate+phosphorus carbonate The composition of limestone+ammonium magnesium hexahydrate and the composition of carbonate apatite+magnesium ammonium hexahydrate in the NMetS group were significantly greater than those in male patients?p<0.05?;the distribution of different calculi components in the MetS group at different ages was not as good as that in the NMetS group Significantly?F=28.114 vs 53.886?.ConclusionsMetS is closely related to the gender,age,calculi location and composition of adult patients with urinary calculi.Clinical diagnosis and treatment of urinary calculi should be based on the patient's gender,age and calculi location and composition to develop an individualized plan,active screening and treatment MetS,the prevention and control of urinary calculi.