The Effect Of Remote Ischemic Postconditioning On The Short-term Prognosis Of Acute Ischemic Stroke

Objective:This study aims to evaluate the feasibility and short-term efficacy of remote ischemic postconditioning(RIPost C)in patients with acute ischemic stroke,and to explore the potential mechanism.Methods:One hundred and sixteen patients with acute cerebral infarction from neurology ward of Anqing Hospital Affiliated to Anhui Medical University were randomly divided into control group and experimental group,the control group was only given standard treatment of cerebral infarction,such as anti-platelet aggregation,regulating lipid and stabilizing plaque,eliminating free radicals,improving circulation,controlling blood pressure and blood sugar etc.For the experimental group,besides standard treatment,the patients were also given RIPost C,and the patients received RIPost C for 7 days,the NIHSS scores,Mean platelet volume(MPV),fibrinogen(FG),D-dimer(DD),high sensitivity C-reactive protein(hs-CRP)and neuron specific enolase(NSE)were measured before and after the treatment.The gender,age,blood pressure,mRS Score,past hypertension and diabetes history and other related factors were evaluated and analyzed,SPSS20.0 statistical software was used to analyze the test data,the NHISS scores and test results of the two groups were compared by two independent samples’ t test.P < 0.05 was considered statistically significant.Results:Before treatment,the NIHSS score of the experimental group was(4.32±2.14),and that of the control group was(4.03±2.37),there was no significant differencebetween the two groups(p > 0.05).After treatment,the NIHSS score of the experimental group was(1.86±1.46)and that of the control group was(3.24±1.98),P< 0.05,the difference between the two groups is statistically significan.Compared with the experimental group before and after treatment,the difference was statistically significant(P <0.05).Compared with the control group before and after treatment,the difference was statistically significant(P <0.05).At the same time,the NIHSS score of the experimental group before and after treatment was(2.46±1.07),and that of the control group was(0.86±0.95),P<0.05,the difference was statistically significant.The difference of MPV,FG,DD,hs-CRP,NSE between the experimental group and the control group was less than 0.05,the difference was statistically significant.No significant adverse events occurred during the treatment.Conclusion:For Acute Cerebral Infarction,compared with conventional treatment,RIPost C can improve the prognosis of patients more effectively.At the same time,the patients had no obvious discomfort and could be tolerated in the whole process.Therefore,ripostc is a simple,noninvasive and well tolerated treatment method,which is effective in the acute phase of cerebral infarction.Its Mechanism of action may be related to the improvement of inflammatory reaction and anti-platelet aggregation.