| Objective:To explore the relationship between the development and distribution of fat and salivary sex hormones in overweight and obese children in early adolescence.The present studyprovides clues about causes of sexual development abnormalities in adolescent obese children and a theoretical basis for preventing and treating childhood obesity.Method:During August-September 2019,66 children from 10 to 13 years old(10years ≤age <13 years)were randomly selected from 3 primary schools in Baota District,Yan’an City,including 41 boys and 25 girls.According to the body mass index(BMI)criteria,they were divided into two groups: the overweight group(30),including 16 boys,14 girls and the obese group(36),including 25 boys and 11 girls.Healthy children with normal weight in the same period were selected as the control group(30),including 12 boys and 18 girls.The height,weight,waist circumference,hip circumference,abdominal skin fold thickness and saliva samples of the three groups of children were measured.The concentrations of testosterone(T)and estradiol(E2)in saliva of all children were measured by the enzyme linked immunosorbent assay(ELISA).Calculate the body mass index(BMI)and waist-hip ratio(WHR)of the three groups of children,and the study data was statistically analyzed.Result:1.Comparison of salivary sex hormone levels among three groups of boys:The differences in saliva testosterone levels among boys between the three groups were statistically significant(P <0.05).After multiple comparisons of LSD,the levels of salivary testosterone in the obese group and the overweight group were lower than those in the normal group,so the difference was statistically significant(P <0.05).The level of salivary testosterone in the obese group was lower than that of overweight group,thedifference was statistically significant(P <0.05).The difference in saliva estradiol levels among the three groups were not statistically significant(P > 0.05).2.Comparison of salivary sex hormone levels among three groups of girls: There was no statistically significant difference in saliva testosterone levels among girls in the three groups(P > 0.05).The difference in saliva estradiol levels among the three groups was statistically significant(P <0.05).After multiple comparisons of LSD,the saliva estradiol level in the obese group was higher than that in the normal group and overweight group,the difference was statistically significant(P <0.05).Although the level of overweight group saliva estradiol was higher than the normal group,the different was not statistically significant(P > 0.05).3.Correlation between BMI,WHR,waist circumference,abdominal skin fold thickness and salivary sex hormone in boys(r):Boys’ BMI,WHR,waist circumference and abdominal skin fold thickness were negatively correlated with saliva testosterone(P <0.05).Boys’ BMI and abdominal skinfold thickness were positively correlated with the saliva estradiol(P <0.05).4.Correlation between BMI,WHR,waist circumference,abdominal skin fold thickness and salivary sex hormone in girls(r):Girls’ WHR,waist circumference,and abdominal skin fold thickness were negatively correlated with saliva testosterone(P <0.05).Girls’ BMI,waist circumference and salivary estradiol were positively correlated(P <0.05).Conclusion:1.There is a gender difference in the effect of obesity on sex hormone levels in the early adolescent children.The saliva testosterone levels of overweight and obese boys significantly reduced,while the saliva estradiol levels of obese girls are increased.2.BMI in the early adolescents is positively correlated with the saliva estradiol levels.However,BMI in early adolescent boys was negatively correlated with the salivary testosterone levels.3.Correlation exists between abdominal fat distribution and sex hormones in saliva.The abdominal fat accumulation in the early adolescents may be related to the level of adolescent sexual stress and needs to be paid attention in the clinical. |
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