Relationship Between White Matter Lesions And Gait And Balance Disorders In Patients With Serious Cerebral Vascular Disease

Objective: To investigate the relationship between white matter lesions and gait and balance disorders in patients with cerebrovascular disease.Methods: January 2018-September 2019 in our hospital during the period of neurology hospital treatment of 182 cases of cerebral small vessel disease(serious cerebral vascular diseases and SCVD)of cerebral White matter lesions(White matter lesions,WMLs)patients as the research object,according to the cerebral White matter lesions score(ARWMC)patients can be divided into mild group(n=72),moderate group(n =73)and severe group(n=37).Step speed,step length,step width,and step frequency were measured and patients' gait and balance were evaluated with SARA score,Tinetti gait score and balance score.SPSS 21.0 statistical software was used for statistical analysis.Results: The baseline comparison of the three groups showed statistically significant differences in the proportion of patients with age,hypertension,diabetes,coronary heart disease,cognitive dysfunction(P<0.05).Abnormal sex,disease,Atrial Fibrillation,history of smoking,drinking,Acute ischemic stroke and cerebral infarction(Acute ischemia stroke,AIS),the proportion of enlarged perivascular space no statistical difference(P>0.05).The age of WML patients increased,the serum uric acid level and blood homocysteine level increased,and the severity of WML also increased.The differences between the three groups were statistically significant(P<0.05).Logistic regression analysis showed that advanced age,hyperuricemia,hyperhomocysteinemia were all risk factors for the severity of WMLs.The results of multi-factor linear regression analysis showed that step width and SARA score were positively correlated with WMLs severity(P<0.05),while Tinetti gait score and balance score were negatively correlated with WMLs severity(P<0.05).Conclusion: Brain white matter lesions mainly affect the gait symmetry,continuity,step width,the severity of white matter lesions is positively related to the patient's age and gait balance disorder,and clarifying the internal relationship can help to identify the progress of white matter lesions early,and reduce the impact of gait and balance dysfunction.