Analysis For White Matter Lesions Of Neurological Department Patients

Background and purpose: White matter lesions (WMLs), which appear as non-specificity matter change periventricular or juxtacortical, frequently seen on health people. But commonly WMLs are related to various geriatric or adult disorders including cerebrovascular diseases, cardiovascular diseases, dementia and psychiatric disorders. So far the pathogenic mechanisms, imaging grading, clinical meaning of WMLs are still in debate. We try to investigate (1) the risk factors of WMLs in neurological department patients and (2) the variance in difference groups.Method: To review and analyze the image and clinical data of 485 neurological department patients who underwent cranium MR and MRA examined from January to December of 2010. Age, sex, clinical history such as hypertension, diabetes mellitus, cardiovascular diseases and stroke, pressure on admission, laboratory test such as blood sugar, total cholesterol, triglyceride, HDL-c (high-density lipoprotein cholesterol), LDL-c (low-density lipoprotein cholesterol) and lipoprotein cholesterol a(LPa), cerebral arteriosclerosis, infarction area were included as the independent variable, and WMLs were included as the dependent variable. Associations between risk factors and WMLs as a binary variable were evaluated using non-conditional logistic regression, which not adjusted for age and gender. A P-value < 0.05 was considered as being significant step by step. The variances in difference groups of WMLs were evaluated using nonparametric test. X 2 test were for sex, clinical history such as hypertension, diabetes mellitus, cardiovascular diseases and stroke, cerebral arteriosclerosis, infarction area. Kruskal-Wallis test were for sex, pressure on admission, laboratory test such as blood sugar, total cholesterol, triglyceride, HDL-c (high-density lipoprotein cholesterol), LDL-c (low-density lipoprotein cholesterol) and lipoprotein cholesterol a(LPa). Result: (1)Age, hypertension, stroke history, cerebral arteriosclerosis are significantly correlated with WMLs. (2)Father more, sex, age, hypertension, systolic pressure on admission and cerebral arteriosclerosis are difference in groups.Conclusion: Age, some vascular risk factors and stroke history are associated with WMLs, The variances in difference groups of WMLs imply that difference risk factors may result in difference shape of WMLs.