A Study On The Application Of Impulse Oscillometry In The Long-term Management Of Asthma In Preschool Children

Objective In recent years,the incidence and prevalence of asthma in children has been increasing year by year;and the assessment of the level of control of asthma and long-term management are still of clinical focus and difficulty.Impulse Oscillometry（IOS）is especially suitable for preschoolers because it does not require special cooperation from their end.This paper aims to evaluate the changing characteristics of IOS in the long-term management of asthma in preschool children to guide clinical treatment.Method From January 2014 to December 2019,71 cases of children with acute,mild and moderate asthma treated at Shengjing Hospital affiliated with China Medical University were the research subjects.The basic information and demographic data of the children,completed IOS and the relevant parameters were obtained.The patients were diagnosed according to GINA 2014"Children’s Bronchial Asthma Diagnosis and Prevention Guidelines"^[12]and were given recommended long-term treatment options for asthma to choose the initial treatment plan.Each treatment plan was adjusted according to the long-term treatment plan.Results Of the 71 cases,47 were male and 24 were female,with an average age of3.31±0.65 years.Z5 at T0,T1,T2,and T3,respectively,is 1.20±0.32,1.09±0.27,1.04±0.21,and 0.95±0.16 kPa/L/s,comparing each segment,apart from T1 to T2,they are all statistically significant（P<0.05）.R5 is 1.13±0.31,1.02±0.26,0.97±0.21,and0.87±0.15 kPa/L/,respectively;comparing each segment,apart from T1 to T2,they are all statistically significant（P<0.05）.R10 is 0.87±0.24,0.82±0.19,0.76±0.16,and0.71±0.14 kPa/L/s,respectively;comparing each segment,they are all not statistically significant（P>0.05）.R20 is 0.67±0.21,0.63±0.16,0.61±0.14 and 0.55±0.14 Hz,respectively;comparing each segment,they are all not statistically significant（P>0.05）.R5-R20 is 0.46±0.22,0.40±0.17,0.36±0.17,and 0.32±0.12 kPa/L,respectively;comparing each segment,only T0 toT1 is statistically significant（P<0.05）.X5 is-0.35±0.24,-0.33±0.18,-0.34±0.13 and-0.35±0.11 kPa/L/s,respectively;comparing each segment,they are all not statistically significant（P>0.05）.AX is 3.90±1.78,3.33±1.55,3.04±1.27 and 2.76±1.01 kPa/L/s,respectively;comparing each segment,only T0 to T1 is statistically significant（P<0.05）.Fres is 26.25±8.84,22.71±6.03,21.41±3.35,and 20.49±2.28 Hz,respectively;comparing each segment,only T0 to T1 is statistically significant（P<0.05）.Conclusion For preschool children post-acute asthmatic attacks,IOS parameters improved to varying degrees with long-term control therapy.Z5,R5,R5-R20,Fres and AX better respond to dynamic changes in asthma treatment.Z5 and R5 showed the highest repeatability and validity.In the long-term management of asthma in preschoolers,using IOS to assess changes in lung resistance is more helpful in evaluating treatment responses to guide the adjustment of treatment options.However,the relationship between IOS and airway inflammation still needs to be studied in depth.