Study On Evaluation Of Curative Effect Of CVA Patients By Impulse Oscillating Method

Objective To observe the changes of the resistance indexes of pulse oscillations in the treatment of patients with cough variability asthma.To explore new methods to evaluate the condition of patients with cough variability asthma,and to provide theoretical basis for clinical treatment.Methods Patients who were screened for initial diagnosis of cough variability asthma in the outpatient department of respiratory medicine,Seventy CVA outpatients were selected randomly to perform bronchial challenge test with IOS andspirometry respectively.Several parameters of airway resistance,including RF,Z5,Rc,Rp,R5,R20,X5as well asFEV1,were measured before and after each challenge with Histamine.Follow up was conducted in third,sixth months of the study.ACT questionnaires,pulmonary function tests,IOS tests and other related items were completed at each follow-up,until the end of the follow-up.The main endpoint of this study was the positive coincidence rate of IOS resistance test and provocation test.Results At the final challenge test,all parameters of IOS were a significant increase in each parameter except Rc(P<0.05).Close linear correlation was found between all resistant parameters and FEV1(P<0.05).Each IOS resistance index was linearly correlated with FEV1,and X5 was negatively correlated with FEV1.The ACT score increased continuously during the follow-up period and had a linear relationship with FEV1(P<0.05).There was a linear relationship between ACT score and IOS resistance index(P<0.05).Conclusions Impulse oscillometry is an alternative method for bronchial hyperresponsiveness measurement.IOS method can be used as an alternative method for airway responsiveness measurement.IOS resistance indices can be used to evaluate the efficacy of cough variant asthma.