| Objective: Epithelial splicing regulatory protein 1(ESRP1)regulates the expression of genes on RNA level as one of epithelial splicing regulatory proteins(ESRPs),and plays an important role in the occurrence and development of malignant tumor.This study aims at investigating the expression and clinical significance of ESRP1 in High grade serous ovarian cancer,and analyzing the possible regulation mechanism preliminarily of promoting metastasis.Methods: Immunohistochemical staining was performed on paraffin tissue samples after surgery to study the expression of ESRP1 in 18 normal ovarian tissues,90 carcinoma tissues and 69 paired-metastatic tissues in order to analyze the relationship between ovarian cancer and clinicopathological factors and the relation between ESRP1 and ECadherin as well as N-Cadherin.Results: 1.The expression of ESRP1 in primary ovarian cancer tissues(4.00(1.55,6.06))was higher than that in normal ovarian tissues(1.20(0.95,2.40))(P=0.02).2.The expression of ESRP1 in ovarian cancer metastasis(5.00(2.00,8.25))was higher than that in primary ovarian cancer(4.50(1.00,6.13))(P=0.042).3.Single factor analysis showed that FIGO stage,peritoneal metastasis and omentum metastasis were related to the high expression of ESRP1(P=0.015,0.018,0.005),and there was no significant relationship with age,abdominal volume,CA125 level or lymph node metastasis.4.ESRP1 expression had a relation with E-cadherin expression in metastatic ovarian cancer(P=0.022),but had no relation with N-cadherin expression.5.High expression of ESRP1 in metastatic ovarian cancer was associated with poor prognosis(P=0.041),while high expression in primary ovarian cancer was not associated with poor prognosis.Conclusion: ESRP1 is related to the occurrence of HGSOC and may enhance the colonization of ovarian cancer cells after the behavior of ovarian cancer cell metastasis and promote the development of ovarian cancer to a certain extent. |
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