Analyze The Risk Factors For Probable Rapid Eye Movement Sleep Behavior Disorder And The Relationship Between PRBD And The Severity Of Cognitive Impairment

Objectives: To study the prevalence and the risk factors for probable rapid eye movement sleep behavior disorder(p RBD)in Chinese rural northeast,and to analyze the relationship between p RBD and the severity of cognitive impairment.Methods: This village-based study included 320 local residents without Parkinson disease and dementia(148 men and 172 women,≥50 years old)in 2018.By a validated questionnaire RBDQ-HK(Chinese RBD questionnaire–Hong Kong),those subjects were divided into p RBD+ group(n=47)and p RBD-group(n=273).Every subject completed a structured questionnaire assessing a variety of risk factors(including age,sex,marriage status,smoking,spirit drinking,physical activity,BMI,and chronic disease status).The cognitive function was assessed by The Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(Mo CA)and Activities of Daily Living(ADL).The logistic regression was used to analyze the relationship between these factors and p RBD after adjustment for potential confounding factors.Results: The prevalence of p RBD is 14.69%(14.86% in men and 14.53% in women).In the fully adjusted model,risk factors that were significantly associated with a higher risk of having p RBD included married status,spirit drinker,exposure of chemicals,benzodiazepines,head injury with conscious impairment,history of hypertension,urinary disturbance.In the age and sex adjusted model,the risk factors included exposure of chemicals,history of hypertension,urinary disturbance,olfactory disturbance and imbalance.We did not find the significant relationship between p RBD and the severity of cognitive impairment.Conclusions: In this village-based study,we found the prevalence of p RBD is 14.69%(14.86% in men and 14.53% in women)and identified many potential risk factors for p RBD,including lifestyle factors,environmental factors and physical factors,providing guidance for the secondary prevention of p RBD.But no significant relationship between p RBD and the severity of cognitive impairment was found in our study.