A Study Of The Relationship Between Human Soluble Lectin-like Oxidized Low Density Lipoprotein Receptor 1 And Long-term Prognosis Of Ischemic Stroke

Objective: To investigate the relationship between human Serum soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1)and the long-term prognosis of ischemic stroke.Methods: A total of 189 patients with acute cerebral infarction admitted in our hospital between December 2015 and January 2017,120 patients with carotid arteriosclerosis but non-acute cerebral infarction and 80 healthy people were enrolled in this study.The risk factors of stroke such as age,gender,smoking,drinking,blood pressure,blood glucose,blood lipid,homocysteine,sLOX-1 and other biochemical indicators were analyzed.The patients were followed up for 3 years.The prognosis of the patients was evaluated by the recurrence rate of cardiovascular and cerebrovascular events,the stability of carotid plaque,the degree of carotid stenosis,the modified Rankin Scale(MRS)score and NIH Stroke Scale(NIHSS)score.The relationship between the level of sLOX-1 and the long term prognosis of ischemic stroke was analyzed to evaluate its value for the prognosis of stroke.Results: during the follow-up,138 cases(73%)were followed up in the acute cerebral infarction group,51 cases(27%)were lost,14 cases(7%)died.The level of sLOX-1 in the poor prognosis group(MRS score 3-6,41 cases)was higher than that in the good prognosis group(MRS score 0-2,97 cases)(2.58 ± 1.38ng/ml vs 1.95 ± 0.94ng/ml,P < 0.05).The level of sLOX-1 in moderate and severe neurological dysfunction group(NIHSS score > 4,20 cases)was higher than that in mild neurological dysfunction group(NIHSS score ? 3,104 cases)(3.23 ± 1.52 ng / ml vs 1.93 ± 0.90 ng / ml,P < 0.05).85 cases(71%)were followed up in the carotid atherosclerosis group,35 cases(29%)were lost and 2 cases(2%)died.The level of sLOX-1 in the recurrent group(40 cases)was higher than that in the non-recurrent group(123 cases)(2.17± 1.13 ng / ml vs 1.71± 0.89 ng / ml,P < 0.05).68 cases were reexamined by color Doppler ultrasonography,and the level of sLOX-1 in the moderate and severe stenosis group(stenosis degree ? 50%,24 cases)was higher than that in the mild stenosis group(stenosis degree < 50%,44 cases)(1.76(1.43,2.83)ng/ml vs 1.50(1.18,2.03)ng / ml,P < 0.05).The level of sLOX-1 in the unstable plaque group(weak echo and mixed echo plaque,45 cases)was higher than that in the non-unstable plaque group(no plaque and strong echo plaque,23 cases)(1.73(1.33,2.48)ng/ml vs 1.38(1.05,1.96)ng / ml,P < 0.05).Conclusion: the level of sLOX-1 is related to the scores of MRS,NIHSS,recurrence rate of cardiovascular and cerebrovascular events,degree of carotid stenosis and plaque stability.Therefore,serum sLOX-1 may be a serum marker for evaluating long-term prognosis of ischemic stroke.