Analysis Of Clinical Characteristic In Different Sodium Ion Concentration Patients With Pulmonary Thromboembolism

Objiective:Analyze the difference of myocardial injury markers,blood routine,coagulation function,renal function,ultrasound cardiagram,embolization site in pulmonary thromboembolism patients of different serum sodium ion concentration.Research the characteristics of hyponatremia in Patients with Pulmonary Embolism.Methods:This trial is a retrospective clinical comparison reasearch.The patients were diagnosed with pulmonary thromboembolism by computed tomographic pulmonary arteriography(CTPA)in the first department of respiratory medicine of the second affiliated hospital of kunming medical university from june 2015 to december 2018 and met the diagnostic criteria of 2019 European heart association guidelines on pulmonary embolism.For all PE patients,vital signs,markers of myocardial injury,emergency biochemistry,blood routine,coagulation function,arterial blood gas analysis,PESI,sPESI,embolization site,ultrasound cardiogram were collected.We defined hyponatremia as a baseline serum sodium level 135 mmol/L or lower.The patients were divided into 2 groups across two levels of serum sodium(>135,?135 mmol/L).We selected 451 patients with a sodium level greater than 135 mmol/L but no larger than 150.8 mmol/L and 97 patients with hyponatremia of sodium level between 107.9 mmol/L and 135 mmol/L.The data of different indicators in each group were statistically analyzed to determine whether there were differences and correlations among the two groups.Results:1.There were no significant differences between two groups in sex,renal function,ultrasound cardiogram,embolization site,sPESI score(P>0.05).2.There were statistically significant differences between two groups in ages,temperature,pulse,PH,PaO2,PaCO2,HCO3-(P<0.05)and statistical differences between two groups also were found in Hb,WBC,NEUT,NLR,AST,CTnT,MYO,BNP,LDH,AT,PT,DD,Prognostic risk model.The comparison of PESI scores between the non-hyponatremia group and the hyponatremia group was statistically significant(P<0.05).3.There was a linear correlation between the level of WBC,NEUT,NLR,AST,AT,PESI scores and serum sodium level,the results were statistically significant(P<0.05).Correlation analysis showed that WBC,NEUT,NLR,AST,PESI scores were negatively correlated with serum sodium level and AT was positively correlated with serum sodium level.Conclusion(s):1.Patients with hyponatremia were older and more likely to had a higher level of WBC,NLR,AST,CTnT,BNP,PESI scores and higher risk stratification of early death at admission compared patients with non-hyponatremia.2.PESI scores may have a better value of evaluation for pulmonary embolism patients with hyponatremia than sPESI scores.3.WBC,NEUT,NLR,AST,PESI scores were negatively correlated with serum sodium level and AT was positively correlated with serum sodium level.