The Clinical Study Of Repeated Transcranial Magnetic Stimulation For Patients With Parkinson's Disease

ObjectiveTo study the effects of repetitive transcranial magnetic stimulation on the recovery of exercise and non-motor symptoms in patients with Parkinson's disease.MethodsFrom November 2016 to December 2018,52 patients with stable Parkinson's disease who were treated in the rehabilitation department of our hospital were randomly divided into treatment group and control group,each group 26.For example,both groups were given conventional medical treatment and active functional training.Patients in the control group were given conventional drugs and rehabilitation training.Patients in the treatment group were given a Magstim Rapid 2 repetitive transcranial magnetic stimulation device on the basis of conventional medicine and rehabilitation training.The two groups of patients were given the same routine rehabilitation training program and time,the treatment group was given low-frequency repetitive transcranial magnetic stimulation treatment,once a day for 15 days,The false stimulation group coils are placed in the opposite direction,and can produce the same frequency as the true stimulation,but no magnetic field output.The Unified Parkinson's Disease Rating Scale(UPDRS)and its functional assessment:mental behavioral mood(UPDRSI),activity of daily living(UPDRSII),and motor function(UPDRSIII),Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)were used before and after the treatment to assess the improvement of patient's exercise and non-motor symptoms.ResultsAmong the 52 patients in this experiment,2 patients quit the experiment halfway,including 1 case in the study group and 1 case in the control group,The rest of the patients successfully completed the 15-day rehabilitation treatment.There were no significant differences in the UPDRS total score,UPDRSI,UPDRSII,UPDRSIII,HAMA and HAMD scales between the two groups before treatment(P>0.05).The UPDRS total score,UPDRSI,UPDRSII,UPDRSIII and HAMD score of the treatment group after treatment was fell than that before treatment(P<0.05).The UPDRS total score and UPDRSIII score of the control group after treatment were fell than those before treatment(P<0.05).The UPDRSI?UPDRSII and HAMD score of control group patients after treatment were not significantly fell than that before treatment(P>0.05).The UPDRS total score,UPDRSI,UPDRSII,UPDRSIII,and HAMD scores in the treatment group were significantly fell than those in the control group(30.05±6.93vs36.53 ± 5.86,1.30±0.25vs1.90±0.34,11.73 ± 1.25vs±3.50±1.79,17.47±1.82 vs20.96±3.63,8.53± 1.34vs11.80±1.92,P<0.05),the HAMA scores of the two groups were not significantly fell after treatment(P>0.05),the HAMA score of the treatment group was not significantly fell compared with the control group(9.58±1.75vs10.04±1.97,P>0.05).Conclusion1.Routine rehabilitation training can improve motor dysfunction in patients,but it is not obvious for mental mood,activities of daily living,depression and anxiety.2.Compared with routine rehabilitation training,repeated transcranial magnetic stimulation can further improve the patient's mental mood,motor dysfunction,activities of daily living and depressive symptoms.3.Routine rehabilitation training and repeated transcranial magnetic stimulation can not improve the patient's anxiety symptoms.