| Objective:Cangfu Daotan Pill is a prescription of Ye Tianshi,a famous doctor in Qing Dynasty.It is designed for those with hypermenorrhea due to fertility and phlegm.In this study,we used the pill combined with lifestyle intervention to treat adolescent PCOS patients with phlegm-dampness,to evaluate its effectiveness and safety,in order to expand the clinical application of the prescription.Method:A total of 120 eligible outpatients from February 2018 to September 201 8 in Yixing Hospital of Traditional Chinese Medicine were randomly divided into experimental group and control group.According to the inclusion,exclusion and exclusion criteria,44 cases in the control group and 48 cases in the experimental group were selected.The experimental group was given Jiawei Cangfu Daotan Pill orally and lifestyle intervention,while the control group was given simple lifestyle intervention.The menstrual cycle,menstrual volume,BMI,WHR,FSH,LH,T,FPG and FINS were observed before t and 3 months after treatment,after 6 months of treatment.the LH/FSH and HOMA-IR ratios were calculated.Data were analyzed and processed by SPSS 19.0 software.Results:(1)Changes in menstruation:In terms of menstrual cycle and Periodic regularity(%),the treatment group after 3 months compared with before treatment,the treatment group after 6 months compared with before treatment,P=0.000,and the control group also hadstatistical significance.After 3 months of treatment,there was no significant difference between the two groups(P>0.05).Both groups can shorten the long cycle of adolescent PCOS patients and make the cycle more regular,and the effect of the two groups is the same.(2)Therapeutic effect of TCM symptoms:After 6 months of treatment,the clinical recovery rate of the experimental group was 83.34%,the marked efficiency was 12.50%,the effective rate was 2.08%,the ineffective rate was 2.08%,the marked rate was 95.84%,and the total effective rate was 97.92%.The clinical recovery rate of the control group was 38.63%,the marked efficiency was 34.10%,the effective rate was 18.18%,the ineffective rate was 9.09%,the marked rate was 72.73%,and the total effective rate was 90.01%.By Wilcoxon rank sum test,P=0.001,the experimental group is better than the control group in improving the clinical symptoms of traditional Chinesemedicine.(3)Changes in BMI and WHR:Compared with before treatment,BMI and WHR of the two groups had statistical significance after 3 months of treatment(P>0.05).The same is true after six months of treatment.After 3 months of treatment,there were significant differences in BMI and WHR between the two groups(P<0.05).The same is true after six months of treatment.It shows that both groups can lose weight,but the experimental group has better weight loss effect,faster effect and higher patient compliance.(4)Changes of Serum Basic Sex Hormone Levels:The changes of serum T,LH,FSH and LH/FSH in the treatment group were studied.It was found that the values of LH,LH/FSH and T in the treatment group were statistically significant after 3 months of treatment compared with those before treatment.The same was true of the control group The values of LH,LH/FSH and T in the treatment group after 6 months compared with those before treatment had statistical significance.The same was true of the control group.After 3 months of treatment,there were significant differences in LH,T,LH/FSH between the two groups(P<0.05),as well as after 6 months of treatment.It shows that the two groups have curative effect on the improvement of serum sex hormones,and the experimental group with Chinese medicine has faster and better therapeutic effect(5)Changes of insulin resistance related indicators:After 3 months of treatment,the insulin resistance indexes in the treatment group had statistical significance compared with those before treatment(P<0.05).The same was true of the control group.After 6 months of treatment,compared with before treatment,the treatment group had statistical significance(P<0.05).The same was true of the control group.After 3 months of treatment,there were significant differences in insulin resistance between the two groups(P<0.05).The same is true after six months of treatment.shows that both groups can reduce blood sugar and insulin resistance,but the effect of the experimental group is better.After 6 months of treatment,the HOMI-IR of most patients in the experimental group is within the normal range,while that of the control group is still highConclusion:The experimental group supplemented with jiawei Cangfu Daotan Pill can not only reduce the weight of adolescent PCOS,waist circumference,but also reduce the serum T,LH,LH/FSH,FINS,FPG values,improve hyperandrogenism and insulin resistance.The curative effect is better than that of the control group.At the same time,in Improving Phlegm-dampness symptoms,the experimental group had a better effect,and there was no abnormal liver and kidney function.Jiawei Cangfu Daotan Pill combined with lifestyle intervention in the treatment of adolescent PCOS is safe and effective. |
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