Prognostic Value Of Preoperative Serum Low-density Lipoprotein Cholesterol In Patients With Clear Cell Renal Cell Cancer

Objective:Numerous studies suggested that dyslipidemia was closely related various cancer and the low density lipoprotein cholesterol(LDL-C)levels were associated with the outcome of cancer patients.However,the predictive value of LDL-C in patients with CCRCC remains unclear.Our study aim is to explore the relationship between the levels of serum LDL-C and prognosis of CCRCC.Methods:308 patients diagnosed with clear cell renal cell cancer(CCRCC)who received surgical treatment were retrospectively enrolled in our study.The necessary clinical data of each enrolled patient were collected.Kaplan-Meier method and the Cox proportional hazards regression model were used to calculate the overall survival(OS)and cancer specific survival(CSS).Results:LDL-C has statistically significant differences in hemoglobin between the two groups(P<0.001).Kaplan-Meier and univariate analysis showed that a lower preoperative serum LDL-C level was risk factor of CCRCC patients.The ROC curve was used to calculate the optimal cut-off value of LDL cholesterol,and the patients were divided into two groups(low-LDL-C group?2.315mmol,n=142;high LDL-C group>2.315mmol/L,n=166).Multivariate analyses demonstrated that a higher serum LDL-C level was closely associated with better OS(HR=0.27,95%CI(0.12,0.61);P=0.002)and CSS(HR=0.19,95%CI(0.08,0.48);P<0.001).Conclusion:Serum LDL-C level is an independent prognostic factor for the overall survival(OS)and tumor-specific survival(CSS)of patients with renal clear cell carcinoma,and can be used as an indicator for the survival and prognosis of patients with renal clear cell carcinoma.