Analysis Of The Clinical Characteristics Of Nontraumatic Intracranial Hemorrhage In Infancy

ObjectiveBy collecting and analyzing the clinical data of infantile non-traumatic intracranial hemorrhage and summarizing its related clinical characteristics,we can better prevent and treat infantile non-traumatic intracranial hemorrhage.MethodsA total of 133 cases of non-traumatic intracranial hemorrhage in infants from 2011 to 2019 in the Pediatric Center of Zhujiang Hospital of Southern Medical University were collected.To develop a questionnaire of clinical data of non-traumatic intracranial hemorrhage in infancy,and record the sex,region,age of onset,time of onset,initial symptoms,main symptoms,positive signs,time from onset to diagnosis,feeding mode,mother’s diet,mother’s birth time,birth age,perinatal condition,blood test related indicators,intracranial hemorrhage site and complications of the child(cerebral infarction,hydrocephalus),pathogenic factors,therapeutic effect and follow-up.Statistical analysis was performed on the data by using composition ratio,chi-square test,Logistic regression analysis,and sensitivity analysis methods.P<0.05 was considered statistically significant.Results1.The incidence of non-traumatic intracranial hemorrhage in infants was significantly higher in males than in females,and the ratio of males to females was about 2:1;the age of onset is mainly from 1 to 2 months(including 2 months),accounting for 54.14%;the feeding mode is mainly pure breast milk feeding,accounting for 56.39%;the first symptoms are vomiting and fever,accounting for 24.81%and 21.05%respectively;the main pathogenic factor is late-onset vitamin K deficiency bleeding,accounting for 46.62%;the main bleeding sites were subarachnoid hemorrhage and subdural hemorrhage,accounting for 51.88%and 5 1.13%respectively.2.Non-traumatic intracranial hemorrhage in infants accounted for 24.06%of secondary cerebral infarction.Further statistical analysis showed that:(1)The chi-square test method showed that there was no statistically significant difference in the incidence of secondary cerebral infarction between single site hemorrhage and multiple site hemorrhage(≥2 sites)(P>0.05).Logistic regression analysis showed that the number of intracranial hemorrhage sites was not related to secondary cerebral infarction,and the difference was not statistically significant(P>0.05).(2)Logistic regression analysis showed that subarachnoid hemorrhage and frontal lobe hemorrhage were correlated with secondary cerebral infarction,which was statistically significant(P<0.05).Subarachnoid hemorrhage was positively correlated with secondary cerebral infarction,while frontal lobe hemorrhage was negatively correlated with secondary cerebral infarction.The sensitivity analysis showed that the accuracy of correlation between frontal lobe hemorrhage and secondary cerebral infarction was low,with no statistical significance(P>0.05).The accuracy of correlation between subarachnoid hemorrhage and secondary cerebral infarction was relatively high,with statistical significance(P<0.05).3.Non-traumatic intracranial hemorrhage in infants accounted for 24.06%of secondary hydrocephalus.Further statistical analysis showed that:(1)The chi-square test method showed that there was no statistical difference in the incidence of secondary hydrocephalus between single site hemorrhage and multiple site hemorrhage(≥2 sites)(P>0.05).Logistic regression analysis showed that the number of intracranial hemorrhage sites was not related to secondary hydrocephalus,and the difference was not statistically significant(P>0.05).(2)Logistic regression analysis showed that intraventricular hemorrhage was positively correlated with secondary hydrocephalus,which was statistically significant(P<0.05).The sensitivity analysis showed that the accuracy of the correlation between intraventricular hemorrhage and secondary hydrocephalus was relatively high,with statistical significance(P<0.05).Conclusions1.The incidence of non-traumatic intracranial hemorrhage in infants was significantly higher in males than in females;the first symptoms are vomiting and fever;the age of onset is mainly from 1 to 2 months(including 2 months);the feeding mode is mainly pure breast milk feeding;the main pathogenic factor is late-onset vitamin K deficiency bleeding.2.Subarachnoid hemorrhage and subdural hemorrhage were the most common hemorrhage sites in infants with non-traumatic intracranial hemorrhage.Secondary cerebral infarction and secondary hydrocephalus were not related to the number of intracranial hemorrhage sites,but related to the intracranial hemorrhage sites.Subarachnoid hemorrhage is prone to secondary cerebral infarction,intraventricular hemorrhage is prone to secondary hydrocephalus.