Plasma NGAL Detection At Very Low/extremely Low Birth Weight Infant Late-onset Sepsis In Clinical Significance

Purposes To study the detection of plasma NGAL in very low/extremely low birth weight infant(VLBWI/ELBWI)late-onset sepsis the value of early diagnosis and prognosis evaluation.Methods January 2017-December 2019 days of age of the south China university affiliated hospital NICU treated > 3 days suspected sepsis VLBWI/ELBWI(research group)as the research object,in the end,according to clinical symptoms and laboratory indexes comprehensive judgment,children can be divided into sepsis with non-sepsis infection group;Sepsis groups according to the illness severity was divided into mild and severe groups.The control group(non-infection group)for the same period of day age admitted in NICU > 3 days without symptoms and signs of VLBWI/ELBWI infection.The team on day 1 disease detection cultivation or bodily fluids,blood and at the onset of 1 day,3days of treatment,and discharge testing plasma NGAL,routine blood,CRP and PCT;Uninfected group 1 day admission NGAL detection of blood.Compare sepsis group,non-sepsis infection group and non-infection group come on day 1 plasma NGAL level differences,analysis of sepsis and non-sepsis group dynamic change NGAL at different time points,compare the hospital sepsis group,the blood level of NGAL non-sepsis infection group and the differences between non-infection group,drawing the first day of onset of NGAL levels predict sepsis ROC curve.Results(1)Sepsis group,the non-sepsis infection,the non-infection group NGAL levels compare different time points: sepsis,non-sepsisinfection group,the non-infected group 1 day the blood level of NGAL comparison,the difference was statistically significant(P< 0.05),two comparison,sepsis group is higher than the non-sepsis infection,the non-infection group,the non-sepsis infection than non-infected group,differences were statistically significant(P< 0.05);Sepsis group was treated with non-sepsis infection,3 days difference was statistically significant(P< 0.05),in comparison,there was no statistically significant difference(P> 0.05).(2)Sepsis group and non-sepsis infection disease 1 day,3 days of treatment,and discharge before and after the blood level of NGAL comparison: Sepsis and non-sepsis infection group blood NGAL levels in the two groups are gradually reduced,the difference had statistical significance(P< 0.05);Two comparison of differences between group had statistical significance(P< 0.05).(3)Sepsis and non-sepsis infection group at discharge NGAL levels with the hospital non-infection group 1 day the blood level of NGAL comparison,there were no statistically significant difference(P> 0.05).(4)Sepsis group blood culture negative and positive onset in children with blood level of NGAL is 1 day,there was no statistically significant difference(P> 0.05).(5)Sepsis mild and severe group come on day 1 blood level of NGAL comparison,the difference was statistically significant(P< 0.05).(6)To build the receiver-the operator(ROC)curve to evaluate the ability of the serum NGAL distinguish sepsis,serum NGAL value to distinguish the sepsis area under the ROC curve is 0.852,the optimal critical value of 205.25 ng/ml,the sensitivity = 84%,specificity = 66.9%.Conclusions1,very low birthweight/extremely low birth weight late-onset sepsis in children with blood NGAL levels,associated with the severity of sepsis,the illness is heavier,the higher the level of NGAL;2,early detection of serum NGAL levels for early diagnosis of VLBW/ELBW late-onset sepsis is of certain reference value.