Clinical Effect Of Wenshenjiangu Decoction On Primary Osteoporosis

Objective:To observe the effect of Wenshenjiangu recipe on bone mineral density,biochemical index of bone metabolism,lumbodorsal joint pain and SPPB score in patients with primary osteoporosis,and to verify the effectiveness and safety of wenshenjiangu recipe.Methods:From March 2019 to October 2019,60 patients with primary osteoporosis that were randomly divided into the treatment group and the control group with 30 cases each.The control group was treated with basic anti-osteoporosis treatment,and the treatment group was treated with wenshenjiangu recipe.After 12 weeks of treatment,the changes of BMD,Biochemical index of bone metabolism,Pain score and SPPB score were recorded and analyzed.Results:(1)Bone density value:intra group comparison:the BMD value of the two groups improved after treatment,but the difference was not statistically significant;inter group comparison:after 12 weeks of treatment,the BMD value of the two groups improved,the treatment group was better than the control group which was not statistically significant.(2)Biochemical indexes of bone metabolism:intra-group comparison:the laboratory indexes of the two groups were significantly improved compared with those before treatment.After 12 weeks of treatment,Ca and P in the treatment group were not significantly increased compared with the control group,while P1NP and ?-ctx were significantly decreased compared with the control group,with statistically significant differences.(3)Lumbodorsal joint pain and SPPB score:intra group comparison:after treatment,the pain score of the two groups was lower than before treatment,while the SPPB score was higher than it;inter group comparison:after 12 weeks of treatment,the pain score of the treatment group was significantly lower than that of the control group,and the SPPB activity score was significantly higher.Conclusion:Wenshenjiangu recipe has good effect and safety in improving biochemical index of bone metabolism,pain and activity score of patients with primary osteoporosis,while has no significantly effect on the BMD.As far as the current feedback data is concerned,wenshenjiangu recipe has a certain effect in the treatment of primary osteoporosis,which can be further applied to clinical treatment under in-depth study.