| OBJECTIVE:Diabetes mellitus is currently considered as one of the international health problems which threaten human health.There are many therapies for the treatment of type 2 diabetes(T2DM),dapagliflozin and liraglutide are effective drugs for the treatment of T2DM,especially for overweight patients with T2DM In this study,we observed the main index,secondary index and incidence rate of adverse reactions of overweight T2DM patients,aim to find a more suitable therapy for overweight patients with T2DM.METHODS:90 overweight patients with T2DM in the Department of Endocrine of Henan Provincial People's Hospital were divided into three groups:dapagliflozin combined with liraglutide group(Dap+Lir group,n=30),liaglutide group(Lir group,n=30)and dapagliflozin group(Dap group,n=30).Dap+Lir group was treated with dapagliflozin,liraglutide injection and metformin.Lir group was treated with liraglutide injection and metformin,Dap group was treated with dapagliflozin and metformin.The three groups were treated for 12 weeks.The general data of patients,such as age,gender,and course of diabetes were collected,and before and after 12 weeks of treatment,glycosylated hemoglobin(HbAlc),fasting blood glucose(FPG),and 2h-postprandial blood glucose(2hPBG),body weight(Wt),body mass index(BMI),among groups were detected.The changes of HbA1c,FPG,2hPBG,Wt and BMI were compared.And the Adverse reactions and complications were observedRESULT:1.The changes of HbA1c,FPG and 2hPBG(1)Changes of HbA1c:Compared with Lir group(6.92±0.81%)or Dap group(7.02±0.87%),HbAl c in Dap+Lir group(6.24±0.81%)decreased significantly after 12 weeks of treatment(all P<0.05)Compared with Lir group(-1.27±0.27%)or Dap group-1.40±0.19%),the Decline level of HbA1c in Dap+Lir group(-2.40±0.6%)decreased significantly(all P<0.05).(2)Changes of FPG:Compared with Lir group(7.09±0.78mmol/L)or Dap group(7.03±0.87mmol/L),FPG in Dap+Lir group(6.38±0.91mmol/L)decreased significantly(all P<0.05).Compared with Lir group(-1.60±0.87mmol/L)or Dap group(-1.26±0.85mmol/L),the Decline level of FPG in Dap+Lir group(-2.61±1.18mmol/L)decreased significantly(all P<0.05)(3)Changes of 2hPBG:Compared with Lir group(9.66±1.08mmol/L)or Dap group(9.80±0.78mmol/L),2hPBG in Dap+Lir group(8.03±1.36mmol/L)decreased significantly(all P<0.05).Compared with Lir group-3.19±1.81mmnol/L)or Dap group(-3.21±1.46mmol/L),the Decline level of 2hPBG in Dap+Lir group(-5.83±2.74mmol/L)decreased significantly(all P<0.05).2.The changes of Wt and BMI.(1)Changes of Wt:Compared with Lir group(-2.23±1.53kg)or Dap group(-1.67±0.87kg),the Decline level of Wt in Dap+Lir group(-3.83±0.65kg)decreased significantly(all P<0.05).(2)Changes of BM:Compared with Lir group(-0.76±0.51kg/m2)or Dap group(-0.58±0.30k2/m2),the Decline level of BMI in Dap+Lir group(-1.31±0.22kg/m2)decreased significantly(all P<0.05)3.Comparison of hypoglycemia and other adverse reactions(1)Incidence of hypoglycemia:Compared with Lir group(0%,0/30)or Dap group(3.30%,1/30),there were no statistical differences in the incidence of hypoglycemia of Dap+Lir group(6.7%,2/30)after 12 weeks' treatment,(all P>0.05).(2)Incidence rates of other adverse reactions:Compared with Lir group(6.7%,2/30)or Dap group(3.3%1/30),there were no statistical differences in the incidence rates of obvious digestive tract reactions of Dap+Lir group(10.0%,3/30)after 12 weeks' treatment,(all P>0.05).No urogenital infection,acute pancreatitis or diabetic ketoacidosis occurred in the three groupsCONCLUSION1.Dapagliflozin Combined liraglutide or monotherapy,all can obviously control blood sugar,and help to reduce body weight and body mass index in the treatment of overweight patients with T2DM.2.Compared with monotherapy of dapagliflozin or liraglutide.dapagliflozin combined with liraglutide is more effective in controlling blood sugar and body weight.And dapagliflozin combined with liraglutide has good safety in the treatment of overweight patients with T2DM. |
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