Clinical Study Of Hypercoagulability In Patients With Colorectal Cancer

Objective:Detection of colorectal polyps,blood coagulation function in patients with colorectal cancer index,analysis of blood coagulation index and tumor pathologic stage,lymph node metastasis,tumor diameter,the relationship between nerve vascular invasion,tumor site,understand the effects of coagulation indexes for colorectal cancer,colorectal cancer compared with patients with colorectal polyps incidence of thrombosis,perioperative treatment in patients with colorectal cancer prevention of thrombosis occurs.Methods:The clinical data of 225 cases of colorectal polyps and 285 cases of colorectal cancer diagnosed by fiber colonoscopy in the first Affiliated Hospital of Kunming Medical University from June 2014 to December 2017 were retrospectively analyzed.All the 510 patients(total)were tested for coagulation function by collecting venous blood before operation.According to the nature of the disease was divided into colorectal cancer group,colorectal polyp group.Comparative analysis of colorectal cancer,colorectal polyp two groups of patients with general conditions such as gender,age and other related indicators as well as coagulation indicators of the differenceAt the same time in different tumor stage,tumor diameter,nerve vascular invasion,tumor location,whether to group with lymph node metastasis,differentiation degree,comparing the difference between the corresponding groups of patients of coagulant function,the incidence of thromboembolism,and then clear influence on blood coagulation function in patients with tumor progress,thus for colorectal cancer patients perioperative blood coagulation intervention to provide theoretical basis.Statistical processing and analysis were performed using SPSS24.0.Results:A total of 285 eligible colorectal cancer patients were included in this study for data collection,including 155 male patients(54.4%)and 130 female patients(45.6%),with a male to female ratio of about 1.19:1 and an average age of 60.12±12.20 yearsIn the observation group,there were 225 patients with colorectal polyps,including 133 males(59.1%)and 92 females(40.9%),with a male to female ratio of about 1.45:1 and an average age of 54.56±12.3 yearsBy univariate analysis,the mean age of patients in the colorectal cancer group and the colorectal polyp group was higher than that in the polyp group,and the difference was statistically significant(P<0.05).The levels of PLT and Fib in the colorectal cancer group were higher than those in the polyp group,and the levels of TT and APTT were lower than those in the polyp group,with statistically significant differences(P<0.05).The levels of PLT,PT and Fib in colon were higher than those in rectum(P<0.05).The levels of PLT,Fib and APTT with the maximum diameter of more than 5 cm were significantly higher than those with the diameter of less than 5cm,and the difference was statistically significant(P<0.05).The levels of PLT and Fib in grade 3-4 of tumor infiltration were significantly higher than that in grade 1-2 of tumor infiltration,and the difference was statistically significant(P<0.05).The coagulation indexes and PLT count showed no difference in nerve invasion,vascular invasion,TNM stage,lymph node metastasis(P>0.05).There were 7 cases of thrombosis in the colorectal cancer group,among which 5 cases occurred after surgery and 2 cases occurred before surgery.No thrombosis was found in the polyp group,and the probability of thrombosis was higher in the colorectal cancer group than in the polyp group,with statistically significant difference(P<0.05,).There were 124 cases of timely and standardized use of anticoagulants after surgery,including 0 cases of thrombosis,and 161 cases of delayed and standardized use of anticoagulants after surgery,including 5 cases of thrombosis(3.11%),the comparison of the two cases(P>0.05).Among the 114 patients who received hemostatic agent after surgery,3 had thrombosis(2.63%);among the 171 patients who did not receive hemostatic agent after surgery,2 had thrombosis(1.17%).The difference between the patients who received hemostatic agent after surgery was not statistically significant(P>0.05)Conclusion:1.Patients with colorectal cancer are prone to abnormal coagulation indexes and are in a state of high coagulation.2.The incidence of thrombosis in colorectal cancer patients was higher than that in colorectal polyps.3.Coagulation abnormalities were more obvious in colorectal cancer patients with tumor diameter greater than 5cm.4.The abnormality of coagulation index was more obvious with the increase of tumor infiltration depth.5.Standard use of anticoagulants during perioperative period can prevent the occurrence of thrombosis in patients with colorectal cancer.