Leptin Erupts The Function Mechanism In The Lung Harm In The Rabbit Impatient Lung Artery Clots

Objective:To study to make impatient lung blood of rabbit to bolt clots disease(APTE) model,(1) observation APTE after TNF-α, the variety of the level of IL-4and β IL-1.(2) Give outside source thin vegetable intervention, observe an outside source thin vegetable to after rabbit APTE TNF-α、IL-1β and super quick C reaction egg white(Hs-CRP) level of influence, study blaze the relation of disease factor and lung hurt and how adjust to control to have protection function to the lung harm.Methods:selection health New Zealand the rabbit is30, random is divided into3sets, matched control(same line the vein inside the neck wear a sting), model set cent matched control in physiology brine(NS), outside source thin vegetable set.Use ELISA method examination serum, the Shu fully goes pathologic analysis.Results:1, after clots IL-4at be taken bad have never seen to heat up in early days, but obviously heated up for6hours after being taken bad, TNF-α and IL-1β level were more obviously high than a matched control.2, pathology check it is thus clear that, the lung blood inside the artery bolts formation after clots, organization atrophy, bleed, the burning respond obviously.3, give the outside source is Leptin set, TNF-α、IL-1β and Hs-CRP level obviously descends;Model matched control in physiology brine is obviously heated up to a healthy matched control.2, pathology sees to lack blood exudation is more obviously light than a model matched control.Conclusions:1, impatient PTE blazed disease factor to take place behind dissimilarity variety, at arouse there is important function in the impatient lung harm.2,The outside source Leptin passes to bolt the level bottom of TNF-α、β IL-1and Hs-CRP to adjust and have protection function to the lung harm thus after clots disease to the impatient lung blood.