Effects Of Iron Deficiency On Drug-induced Addiction Memory

Objective:This study investigated the effect and potential mechanisms on iron-deficiency alleviate addiction memory.Methods:The effect of iron-deficiency on addiction memory was examined by using the behavioral modes of addiction,like the conditioned place preference/aversion(CPP/CPA)and locomotor activity in the mice fed with low-iron diet for at least three weeks as compared with the control mice with normal diet.The Morris water maze(MWM)and contextual fear conditioning test,for which the hippocampus plays a crucial role,were also examined in the iron-deficiency mice.Results:We found that the addictive drugs such as methamphetamine or morphine induced significant CPP/CPA in the control mice,but that was significantly reduced in the iron-deficiency mice.The sensitization of the locomotion induced by methamphetamine was suppressed in the iron-deficiency mice relative to the control mice.However,the Morris water maze(MWM)and contextual fear conditioning test revealed that iron-deficiency itself did not affect these two types of memory,but interestingly,either methamphetamine or morphine treatment impaired the memories only in the iron-deficiency mice.Conclusion:The present data indicate that iron-deficiency itself does not affect the hippocampus-dependent memories but produces lower vulnerability to confer the methamphetamine/morphine-induced addictive and mnemonic-dependent behaviors.