Study On The Correlation Between Metabolic Syndrome And Clinicopathological Features Of Prostate Cancer

BackgroundProstate cancer(PCa)is one of the most common malignant tumors in men.The incidiance is highest in male malignant tumors in Eurpope and the United States,while the fatality rate ranks second.In the past 10 years,the incidence of PCa in China was increasing rapidly.The average annual increase is 12.07%.And also,due to the aging society,PCa will become a urinary malignant tumor that seriously threaten the health of Chinese men.Multiple studies have shown that metabolic syndrome(MetS)and its components are closely related to the development of a variety of cancers.And although many studies have reported the closed relationship between MetS and the development of PCa,it is still controversial that whether MetS is a risk factor for PCa.At present,the studies about the correlation between MetS and Gleason score,tumor staging and bone metastasis of PCa are limited.Therefore,it is important to further study the relationship between MetS or its components and the development of PCa.In this study,we reported the relationship between MetS or its components and the incidence of PCa indcidicance and clinical parameters,including positive rate of prostate biopsy,Gleason score,tumor T stage and bone metastasis,through a combination of retrospective analysis,systematic review,and meta-analysis to provide theoretical basis for clinical PCa diagnosis and treatment.Method1.Retrospective analysis of clinical and pathological data of 187 patients who received prostate biopsy and diagnosed with PCa from January 2014 to December 2018 in Nanfang Hospital.According to PCa Gleason score,cases were divided into GS?4+3 and GS<4+3 groups;T stage was divided into>T2c group and<T2c group;bone metastasis group and bone metastasis group were divided according to bone metastasis.T test and Chi-square test were used to analyze the relationship between MetS and its components with PCa Gleason score,tumor T stage and bone metastasis.2.The system searches Pubmed,Cochrane,Embase,and Web of Science databases for research related to MetS and PCa.Cohort and case-control studies of prostate cancer and MetS were included in the Cochrane Evaluation Manual system.The literature was screened by two independent researchers,following by data extraction and quality control.The meta-analysis was performed using RevMan5.3 software.The main objective was to analyze the relationship between MetS and the occurrence of PCa,the relationship between MetS and PCa pathology Gleason score and the relationship between MetS and PCa tumor T stage.The relationship between MetS and the occurrence of PCa was grouped and analyzed according to the selection of the study population included in the literature:?analysis of the relationship between MetS and PCa overall incidence(the included studies were 10 longitudinal cohort studies of people who did not have PCa at the starting point),? analysis the relationship between MetS and the positive rate of prostate biopsy(including 9 prostate biopsy studies in patients with indications for prostate biopsy),?analysis the relationship between MetS and PCa(including 4 case-control studies of PCa and non-PCa).Result1.Retrospective analysis results show that patients with MetS have a significantly higher risk of high-grade disease(Gleason>4+3)than patients without MetS(OR=2.064,95%CI:1.503-4.047),and are more likely to develop high-T stage PCa(T stage?T2c)(OR=2.274,95%CI:1.047-4.973),and the risk of bone metastasis was significantly increased(OR=2.502,95%CI:1.323-4.720).2.The meta analysis results showed that:? the analysis result of 10 longitudinal cohort studies of people without PCa at the starting point shows that there was no significant correlation between MetS and the overall incidence of PCa(RR=0.99,95%CI:0.84-1.17).? The analysis rusult of 9 prostate biopsy studies shows that patients with MetS had a significantly higher risk of positive prostate biopsy than non-MetS patients(OR=1.29,95%CI:1.17-1.42).?The analysis results of case-control studies between PCa patients and non-PCa patients showed that MetS patients had a significantly higher risk of PCa than non-MetS patients(OR=1.58,95%CI:1.27-1.96).?The analysis results of the relationship between MetS and PCa pathology Gleason score show that the risk of high-grade PCa in PCa patients with MetS is significantly increased(OR=1.66,95%Cl:1.53-1.80)and the analysis results of the relationship between MetS and PCa tumor T stage show that PCa patients with MetS have a significantly increased risk of high-stage PCa(OR?1.27,95%CI:1.19-1.34).ConclusionThe relationship between MetS and PCa remains unclear;however patients with MetS have a significantly higher risk of high-grade disease,and they were prone to tumor T staging and distant bone metastasis.