Detection And Analysis Of The Blood Lipid Level And Liver And Kidney Function For Parkinson's Disease

Parkinson's disease has become the second most common neurodegenerative disease after alzheimer's disease.The number of people diagnosed with Parkinson's disease in China is increasing year by year.Up to now,there is no cure plan for Parkinson's disease,and the treatment effect of late Parkinson's disease is poor,resulting in poor life quality of Parkinson's disease patients,which will bring heavy mental burden and economic pressure to the patients themselves,their families and even the society.It is therefore important to identify biochemical markers for the early diagnosis of Parkinson's disease.Due to oxidative stress and mitochondrial dysfunction playing a very important role in the many pathogenesis of Parkinson's disease,the author consider that there may be a correlation between the indicators of liver and kidney function and the blood lipid level and Parkinson's disease.Therefore,in this paper,detection and analysis of the blood lipid level and liver and kidney function for Parkinson's disease will be studiedObjective:through the determination of Parkinson's disease index of liver function,renal function and blood lipid test level,find glutamate amino transferase,aspartate aminotransferase,total bilirubin,direct bilirubin,indirect bilirubin,uric acid,creatinine and urea nitrogen,and total cholesterol,triglycerides,high-density lipoprotein cholesterol(HDL),low density lipoprotein cholesterol(LDL)and the relationship between the Parkinson's disease.Methods:This paper was conducted by case-control study.Chose patients who were diagnosed with Parkinson's disease from July 2017 to January 2020 in the Y angtze university affiliated first people's hospital and clinics,eliminating the pati ents with Parkinson's syndrome,caused by cerebrovascular disease or encephaliti s,or with diseases in heart,lung and digestive(hepatobiliary).Parkinson's disease group(mean age 67.3 years)included 73 males and 102 females.Based on clinical diagnosis,Parkinson's disease patients were divided into two groups:86 patients in the short-range group(disease duration ?2 years),including 32 males and 54 females.There were 89 patients in the long range group(>for 2 years),including 41 males and 48 females.Demographic data,such as gender,age,disease course and composition of middle and old people,were collected from the short-range group,the long-range group and the normal control group,and biochemical indexes of liver function,renal function and blood lipid were measured and recorded.During the same period,215 healthy people with age and gender matching were randomly selected by the physical examination center as the normal control group(average age:67.3 years),including 89 males and 126 females.Demographic data,such as gender,age,disease course and composition of middle and old people,were collected from the normal control group,and biochemical indexes of liver function,renal function and blood lipid were measured and recorded.SPSS25.0 software was used to test the age,sex,number of people and number of middle-aged and elderly people in Parkinson's group and normal control group.The measurement data were expressed in the form of mean ± standard deviation(x±s).Then the biochemical indexes of liver function,renal function and blood lipid in the short-range group,the long-range group and the normal control group were tested by nonparametric method,and the results were expressed by median(lower quartile to upper quartile).Results:(1)There were no significant differences in age,gender,and composition of middle and old age between the PD group(including the short-range group and the long-range group)and the normal control group(P>0.05).(2)The results of ALT,AST,TB and IBIL in the Parkinson's group(including the short-range group and the long-range group)and the normal control group were significantly lower than those in the normal control group(P<0.05).(3)Both the Parkinson's group(including the short-range group and the long-range group)and the normal control group had significantly lower UA values in renal function indexes than the normal control group(P<0.05).(4)the TC,TG and HDL values of pd group(including short-range group and long-range group)and normal control group were significantly lower than those of normal control group(P<0.05).(5)The detection values of Cr and BUN in the short-range group were significantly lower than those in the normal control group(P<0.05),and the detection values of Cr and BUN in the short-range group were also significantly lower than those in the long-range group(P<0.05).(6)LDL in the long range group was significantly lower than that in the normal control group(P<0.05),and there was no significant difference between the long range group and the short range group(P>0.05).(7)the UA and Cr values of male Parkinson's disease patients were significantly higher than those of female Parkinson's disease patients(P<0.05).Conclusion:In this study,it was found that:(1)serum values of ALT,AST,TB,IBIL,TC,TG,HDL,UA and UA/Cr in Parkinson's disease patients were significantly lower than those in normal people and had nothing to do with the course of disease;(2)the levels of BUN and Cr were significantly reduced in patients with Parkinson's disease at early stage,and the levels of LDL were significantly reduced in patients with Parkinson's disease at late stage.(3)TB,DB,UA and Cr in male pd patients were significantly higher than those in female pd patients,while TC,TG and LDL in female PD patients were significantly lower.There was no significant difference in ALT,AST,IBIL,BUN,UA/Cr between different genders.In conclusion,serum values of ALT,AST,TB,IBIL,TC,TG,HDL,UA and UA/Cr can be considered for the diagnosis of Parkinson's disease.