| Objective: To explore whether migraine can cause cognitive dysfunction;To explore the relationship between migraine and affective disorder,namely comorbid anxiety and depression,and the impact and correlation of anxiety and depression of different severity on cognitive function;Correlation of characteristics such as headache intensity,headache frequency,duration of each headache,and cognitive dysfunction.Methods: The case group data were selected from a total of 102 patients with migraine from September 2018 to December 2019 in the neurology clinic and hospitalization of Liaoning Provincial People's Hospital.The data of the control group were selected from a total of 65 healthy people who were matched with the age,gender,and education level of the case group at the physical examination center of Liaoning Provincial People's Hospital in the same period.The main scales used in the study were diagnostic criteria for migraine in ICHD-3,self-rating anxiety scale(SAS),self-rating depression scale(SDS),Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(Mo CA).The case-control method was used to compare the differences in cognitive function between the case group and the control group.Migraine patients with comorbid anxiety and depression were screened out according to SAS and SDS criteria,and then divided into three groups: mild,moderate and severe anxiety and depression according to their different severity.The differences of cognitive function between migraine non-anxiety and depression group and migraine comorbid mild,moderate and severe anxiety depression group were compared.The correlation between the clinical characteristics of migraine,the severity of comorbid anxiety and depression,and cognitive impairment was analyzed.All data were statistically analyzed using the SPSS 24.0 statistical software package.There was a statistically significant difference at the definition of P <0.05.Results: Compared with the control group,the differences between the case group and the control group were statistically significant(P <0.05),and there were significant differences in attention,language fluency,and delayed memory(P <0.001);The difference was not statistically significant on MMSE and SAS(P> 0.05).The severity of migraine comorbid anxiety and depression was negatively correlated with MMSE,Mo CA and other variables,that is,the more severe the comorbid anxiety and depression of migraine patients,the more obvious their cognitive impairment,and the difference was statistically significant(P <0.05),except Mo CA's language fluency cognition area(P> 0.05).Moreover,the clinical characteristics of migraine were negatively correlated with impairment of cognitive function,and the difference was statistically significant(P <0.05),with the exception of HIT-6(P> 0.05).Conclusion: Cognitive dysfunction exists in patients with migraine,which is mainly manifested in serious impairment in attention,language fluency and delayed memory.The severity of migraine comorbid anxiety and depression is negatively correlated with the results of MMSE and Mo CA,that is,the more severe the comorbid anxiety and depression of migraine patients,the more obvious their cognitive impairment is.Except for the cognitive domain of fluency in Mo CA.Moreover,clinical characteristics of migraine,such as headache intensity,headache frequency,and headache duration,were also negatively correlated with cognitive impairment.Prompts us to pay close attention to the cognitive function of migraine patients with severe headache intensity,high frequency of headaches,long duration of each headache and comorbid severe anxiety and depression.It is recommended to use Mo CA to screen out migraine patients with cognitive impairment as soon as possible Intervention or treatment early. |
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