Expression And Clinical Significance Of CIP2A And E2F1 In Endometrial Carcinoma

Objective: By detecting the expression of CIP2 A,a cancer inhibitor of protein phosphatase 2A,and E2F1,a transcription factor,in different endometrial tissues,and combining with the clinicopathological parameters,we preliminarily explored whether CIP2 A and E2F1 could be potential biomarkers of endometrial cancer,and analyzed whether they had interaction in the development of endometrial cancer.Methods: From March 2016 to June 2019,112 cases of different endometrial tissues confirmed by pathology department of our hospital were collected.All the clinical and pathological data were completed.The positive expression rate of CIP2 A and E2F1 in different endometrial tissues was detected by IHC.The relationship and correlation between CIP2 A and clinicopathological parameters of endometrial carcinoma were analyzed by statistical method.(2)Results:(1)CIP2A was mainly expressed in the cytoplasm,the positive expression was brownish yellow or brown granules.The positive expression rates of CIP2 A in normal endometrium,atypical hyperplasia endometrium and endometrial carcinoma were 26.70%,50.00% and 74.10% respectively.The positive expression rate of CIP2 A in endometrial cancer tissue was significantly higher than that in normal endometrial tissue and atypical hyperplasia endometrial tissue,and the difference with statistical significance(P<0.05);(3)E2F1 was mainly expressed in the nucleus,the positive expression was brown or brown granules.The positive expression rates of E2F1 in normal endometrium,atypical hyperplasia endometrium and endometrial carcinoma were 26.70%,54.20% and 84.50% respectively.The positive expression rate of E2F1 in endometrial cancer tissue was significantly higher than that in normal endometrial tissue and atypical hyperplasia endometrial tissue,and the difference with statistical significance(P<0.05);(4)The correlation between the expression of CIP2 A and E2F1 in endometrial carcinoma and clinicopathological parameters:(3.1)the positive expression rate of CIP2 A in endometrial cancer patients with myometrial invasion depth ? 1/2 was higher than that in patients with myometrial invasion depth <1/2,the difference was statistically significant(P<0.05);(3.2)There was no significant correlation between the expression of CIP2 A and patients' age,FIGO stage,pathological type,differentiation degree,ER,PR,cervical canal involvement;(3.3)There was no significant correlation between the expression of E2F1 and patients' age,FIGO stage,pathological type,differentiation degree,ER,PR,cervical canal involvement,accessory involvement and myometrial infiltration depth(P>0.05);(5)Correlation between CIP2 A and E2F1 expression in endometrial carcinoma: through Spearman rank correlation analysis,there was no significant correlation between CIP2 A and E2F1 expression in endometrial carcinoma(r =0.073,P=0.585).Conclusion: 1.With the aggravation of endometrial lesions,the positive expression rate of CIP2 A and E2F1 also increased,which may play a role in the occurrence and development of endometrial cancer,and can be used as a potential biomarker;2.The positive rate of CIP2 A is related to the depth of myometrial invasion;3.The expression of CIP2 A and E2F1 in endometrial cancer is not significantly related,and the expression of CIP2 A and E2F1 in endometrial cancer is not significantly related It may affect the development of endometrial cancer in different ways.