Effects Of Guipi Decoction Combined With Tranexamic Acid On Perioperative Blood Loss Of Total Hip Arthroplasty

Objective: To observe the effect of Guigui Decoction combined with tranexamic acid injection before surgery on the reduction of blood loss during perioperative period of total hip arthroplasty for elderly femoral neck fractures,and to explore the effect of Guipi Decoction on perioperative blood loss.Mechanism of action and safety.Methods: Sixty patients with femoral neck fractures who met the inclusion criteria from January 2019 to January 2020 were selected from the Department of Joint and Sports Medicine and the Department of Orthopaedics and Limology of Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,according to the order of admission.Numbered 1-60,using Rand A 1.0(Randomization Adviser 1.0)software,the patients were randomly divided into two groups,each with 30 patients.The observation group(guipi decoction plus intravenous tranexamic acid group))Oral Guipi Decoction 1 day before THA operation to 14 th day after operation(1 pair daily,morning and evening);Tranexamic acid sodium chloride injection(1g: 100ml)intravenously for 30 minutes before surgery Bleeding.The control group(simple intravenous drip of tranexamic acid group)was given intravenous drip of tranexamic acid sodium chloride injection(1g: 100ml)30 minutes before THA operation to prevent bleeding.Preoperative and surgical approaches of the two groups of patients And postoperative routine anticoagulation are the same.Compare the two groups of patients with general information such as age,sex,weight,height,course of disease,affected side,and basic medical diseases.Record the two groups before,1 day,7 days after surgery,and 14-day Hb and HCT values;intraoperative blood loss,drainage volume 48 hours after surgery,and blood transfusion;7 pairs of lower extremity arteriovenous color Doppler ultrasound before and after surgery.Operators arrive at a total amount of blood loss,bleeding dominant,recessive blood loss.Diff more than two sets of data,analyze the data by SPSS 23.0 software,concluded.Results: There was no significant difference in age,gender,weight,height,course of disease,affected side,and basic medical diseases between the two groups(P> 0.05).Both lower extremity arteriovenous color Doppler ultrasound was performed before and 7 days after surgery.By comparison,the difference was not statistically significant(P> 0.05),and arteriovenous color Doppler examination of both lower extremities did not show venous embolism.Hb and HCT were compared between the two groups before,1,7,and 14 days after operation.(P<0.05),Hb and HCT in the observation group were higher than those in the control group.There was no significant difference in blood loss,postoperative drainage,and blood transfusion between the two groups(P> 0.05).There was no statistical significance in the comparison of bleeding volume(P> 0.05),while the difference in hidden bleeding volume and total blood loss was statistically significant(P<0.05).group.Conclusion: The observation group is better than the control group in reducing blood loss during perioperative period of total hip arthroplasty in elderly femoral neck fractures,and Guipi Decoction does not increase the risk and adverse reactions of postoperative venous thrombosis,which is worthy of clinical application.