Efficacy Of Topical Administration Of Iodine Tincture In Modified Radical Mastectomy On Reducing Subcutaneous Effusion

BackgroundSubcutaneous effusion refers to the fluid accumulation between the skin flap and chest wall or in the axillary cavity after modified radical mastectomy,which is one of the most common postoperative complications after modified radical mastectomy.If a small amount of subcutaneous effusion occurred after the operation,following measures such as adequate local suction,enhancing dressing change,supplementing with the symptomatic treatment of elastic chest band compression bandaging in the surgical area.It does not affect the prognosis of most patients.However,the recovery period of massive subcutaneous effusion is long,which extending the time of the postoperative drainage tube duration and hospitalization duration,bringing pain to the patient both physically and mentally,and delaying the postoperative radiotherapy,chemotherapy and other treatment plans.ObjectiveTo investigate the efficacy of topical administration of 2% iodine tincture in modified radical mastectomy on reducing subcutaneous effusion and provide reference basis for formulating effective measures to prevent subcutaneous effusion.MethodsFrom May 2018 to March 2019,a total of eighty-one patients undergoing modified radical mastectomy at the First Affiliated Hospital of Xinxiang Medical University were enrolled prospectively in this study.According to the random number,they were divided into two groups.41 patients in the experimental group were administrated 2% iodine tincture in the surface of operative wounds,and 40 patients in the control group were administrated 0.9% sodium chloride injection.Comparison based on age,body mass index,occupation,education background and the postoperative pTNM stage between the experimental and the control group was conducted.The following data were compared as postoperative drainage volume 1 day,2 days and 3 days after operation,postoperative drainage tube duration and hospitalization duration,and the incidence of postoperative complications such as subcutaneous effusion,flap necrosis,fever and incision infection between the two groups.Follow-up information was available between the two groups after the operation.Results1.There was no significant difference based on the age,body mass index,occupation,education background and the postoperative pTNM stage between the experimental group and the control group.2.The average postoperative drainage volume 1 day,2 days and 3 days after operation in the experimental group was 92.0±6.5ml,60.9±5.5ml and 47.2±6.5ml,which were respectively lower than that of the control group(96.4±5.3ml,66.3±5.4ml and 51.3±5.7ml).The postoperative drainage tube duration and hospitalization duration were 7.5±0.9d and 16.2±1.2d,which were respectively lower than that in the control group(8.8±1.0d and 18.9±1.3d).3.The incidence of postoperative subcutaneous effusion in the control group was 20.0%(8 cases),which is higher than that in the observation group(4.9%)(2 cases).4.The incidence of postoperative flap necrosis was 5.0% in the control group(2 cases),and 7.3% in the observation group(3 cases).5.No fever or incision infection occurred in the two groups.6.No local recurrence or metastasis occurred in follow-up visits.ConclusionTopical administration of 2% iodine tincture in modified radical mastectomy can effectively reduce postoperative drainage volume and prevent subcutaneous effusion.