Risk Factors Of Helicobacter Pylori Eradication Failure In Southern Anhui Province

Objective:To compare the efficacy of different quadruple therapy in the eradication of Helicobacter pylori in southern Anhui,and to explore the risk factors of Helicobacter pylori eradication failure.Methods:351 patients with Hp infection diagnosed by ¹⁴C-UBT in the Department of Gastroenterology,the First Affiliated Hospital of Wannan Medical College from October 2018 to April 2019 were selected as the study objects.The patients were randomly divided into 4 groups,and different treatment schemes were used.PPIs in the scheme were esmeprazole and rabeprazole,which were less affected by the individual.Regimen A esmeprazole+clarithromycin+amoxicillin+colloidal pectin bismuth,regimen B rabeprazole+clarithromycin+amoxicillin+colloidal pectin bismuth,regimen C ivzontriple?tinidazole+clarithromycin+bismuth potassium citrate?,regimen D rabeprazole+ivzontriple,the course of treatment is 14 days.Four weeks after the end of treatment,¹⁴C-UBT was used to check whether Hp eradication was successful.A questionnaire was used to record the general condition of the patient?age,gender,body mass index,residence,occupation,monthly income,education?,living habits?number of teeth brushing,smoking,drinking?,and health status?hypertension,diabetes,gastroscopy Performance?,treatment plan and other information.The risk factors of Hp eradication failure were determined by statistical analysis.Results:Among 351 patients,299 patients successfully eradicated Hp,and 52 patients failed,with an eradication rate of 85.19%.The number of patients using A,B,C,and D treatments was 91,104,83,and 73,respectively,and the eradication rates were92.3%,91.3%,78.3%,and 75.3%.The univariate analysis showed that there was no correlation between the factors and the eradication rate in the general situation of patients?age,gender,body mass index,residence,occupation,monthly income,education??P>0.05?.Among the living habits factors,smoking was the only one that led to the reduction of eradication rate?P<0.05?.There was no correlation between the frequency of brushing and alcohol consumption and eradication rate?P>0.05?.Diabetes significantly reduced the eradication rate among all factors of health status?P<0.05?,and there was no correlation between hypertension and endoscopic performance and eradication rate?P>0.05?.The two PPIs used in this study had no significant effect on the eradication rate?P>0.05?;the selection of antibiotics had a significant effect on the eradication rate?P<0.05?,which may be related to drug resistance.Multivariate analysis showed that smoking,diabetes,and different eradication strategies were independent risk factors for Hp eradication failure in southern Anhui.Conclusion:Smoking,diabetes,and different eradication strategies are independent risk factors for Hp eradication failure in southern Anhui.When eradicating Hp,appropriate treatment should be selected according to the patient's health status and local drug resistance,so as to inform the patient of the importance of good living habits and avoid eradication failure.